• Novel Peroxisomal Localization of Sirtuin 3 and its Biological Implications

      Padia, Ravi N.; Department of Biochemistry and Molecular Biology (2014-04)
      Post translational modifications (PTMs) such as phosphorylation, acetylation, ubiquitination, methylation, SUMOylation etc. serve to add another level of complexity and functional diversity to the proteome. These PTMs serve to generate a distinct signal which can then regulate the functionality of the protein harboring one or more of these PTMs and hence ultimately regulating the associated signaling/biological pathway. Some of the ways in which PTMs can bring about the change in the functionality of proteome is by influencing the sub-cellular localization of proteins, protein-protein, protein-DNA, protein-RNA interactions, activity of enzymes, protein turnover, oligomerization of proteins etc. Further, a combination of two or more PTMs can bring about another layer of regulation where presence of a particular combination of PTMs is obligatory to elicit the regulatory message (Yang and Seto 2008a).