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dc.contributor.authorWilkins, Thad
dc.contributor.authorJarvis, Kathryn
dc.contributor.authorPatel, Jigneshkumar
dc.date.accessioned2014-05-06T19:20:49Z
dc.date.available2014-05-06T19:20:49Z
dc.date.issued2011-12-15
dc.identifier.citationDiagnosis and management of Crohn's disease. 2011, 84 (12):1365-75 Am Fam Physicianen
dc.identifier.issn1532-0650
dc.identifier.pmid22230271
dc.identifier.urihttp://hdl.handle.net/10675.2/316533
dc.description.abstractCrohn's disease is a chronic inflammatory condition affecting the gastrointestinal tract at any point from the mouth to the rectum. Patients may experience diarrhea, abdominal pain, fever, weight loss, abdominal masses, and anemia. Extraintestinal manifestations of Crohn's disease include osteoporosis, inflammatory arthropathies, scleritis, nephrolithiasis, cholelithiasis, and erythema nodosum. Acute phase reactants, such as C-reactive protein level and erythrocyte sedimentation rate, are often increased with inflammation and may correlate with disease activity. Levels of vitamin B12, folate, albumin, prealbumin, and vitamin D can help assess nutritional status. Colonoscopy with ileoscopy, capsule endoscopy, computed tomography enterography, and small bowel follow-through are often used to diagnose Crohn's disease. Ultrasonography, computed axial tomography, scintigraphy, and magnetic resonance imaging can assess for extraintestinal manifestations or complications (e.g., abscess, perforation). Mesalamine products are often used for the medical management of mild to moderate colonic Crohn's disease. Antibiotics (e.g., metronidazole, fluoroquinolones) are often used for treatment. Patients with moderate to severe Crohn's disease are treated with corticosteroids, azathioprine, 6-mercaptopurine, or anti-tumor necrosis factor agents (e.g., infliximab, adalimumab). Severe disease may require emergent hospitalization and a multidisciplinary approach with a family physician, gastroenterologist, and surgeon.
dc.language.isoenen
dc.rightsArchived with thanks to American family physicianen
dc.subject.meshAnti-Inflammatory Agents
dc.subject.meshCrohn Disease
dc.subject.meshDisease Management
dc.subject.meshDisease Progression
dc.subject.meshEndoscopy, Gastrointestinal
dc.subject.meshGlucocorticoids
dc.subject.meshHumans
dc.subject.meshImmunosuppressive Agents
dc.subject.meshMagnetic Resonance Imaging
dc.subject.meshTomography, X-Ray Computed
dc.subject.meshTumor Necrosis Factor-alpha
dc.titleDiagnosis and management of Crohn's disease.en
dc.typeArticleen
dc.contributor.departmentDepartment of Family Medicineen
dc.identifier.journalAmerican family physicianen
refterms.dateFOA2019-04-09T19:24:21Z
html.description.abstractCrohn's disease is a chronic inflammatory condition affecting the gastrointestinal tract at any point from the mouth to the rectum. Patients may experience diarrhea, abdominal pain, fever, weight loss, abdominal masses, and anemia. Extraintestinal manifestations of Crohn's disease include osteoporosis, inflammatory arthropathies, scleritis, nephrolithiasis, cholelithiasis, and erythema nodosum. Acute phase reactants, such as C-reactive protein level and erythrocyte sedimentation rate, are often increased with inflammation and may correlate with disease activity. Levels of vitamin B12, folate, albumin, prealbumin, and vitamin D can help assess nutritional status. Colonoscopy with ileoscopy, capsule endoscopy, computed tomography enterography, and small bowel follow-through are often used to diagnose Crohn's disease. Ultrasonography, computed axial tomography, scintigraphy, and magnetic resonance imaging can assess for extraintestinal manifestations or complications (e.g., abscess, perforation). Mesalamine products are often used for the medical management of mild to moderate colonic Crohn's disease. Antibiotics (e.g., metronidazole, fluoroquinolones) are often used for treatment. Patients with moderate to severe Crohn's disease are treated with corticosteroids, azathioprine, 6-mercaptopurine, or anti-tumor necrosis factor agents (e.g., infliximab, adalimumab). Severe disease may require emergent hospitalization and a multidisciplinary approach with a family physician, gastroenterologist, and surgeon.


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