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    Subjects9d813c66-9668-43fb-ab9e-921b1c3231b1 (5)DNA (5)Anemia (3)e6652b09-fbe9-4434-9ff3-d320035740a0 (3)07046b7d-23f2-4a47-916d-95c3ddf23097 (2)View MoreAuthors
    Department of Cell and Molecular Biology (63)
    Counts, David F (2)Agee, Julia (1)Anderson, Ann Stuart (1)Apelgren, Lynn David (1)View MoreTypesDissertation (61)Thesis (2)

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    Protein kinase C and contraction in rabbit iris smooth muscle

    Howe, Phillip H (1988-03)
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    The relationship between nonenzymatic glycation of lens crystallins and diabetic cataract formation

    Perry, Ronald E (1986-03)
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    Assessment of the immune status of dialysis of patients following donor specific blood transfusions

    Kapp III, William Karl (1985-06)
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    The VL region of IgG GAR and its role in anti-flavin specificity

    Kiefer, Charles R (1981-05)
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    Reactivation of latent herpes simplex virus and chemotherapy of herpes infection

    Se Kwon, Byoung (1980-12)
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    An early 'phosphoinositide effect' in poliovirus infected HeLa cells

    Pickard, Cheryl Lewis (1985-06)
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    Recombination and genetic polymorphism at the mouse alpha-globin locus

    Lewis, Jill B (1988-12-08)
    Unusual genetic phenomena are often responsible for dramatic evolutionary changes at many mammalian loci. Among the possible genetic mechanisms involved in these changes are point mutation, gene-conversion, and homologous or nonhomologous recombination. Rarely can such evolutionarily significant events be studied as recent occurrences in mammalian systems. In most case.s it can only be postulated that such events occurred ·in the distant past. In the case analyzed in this research, however, the genetic rearrangement has occurred within the last fifteen years since the origination of a certa~n inbred mouse strain known as AKXL-7. The AKXL-7 recombinant inbred strain is the product of inbred parental strains AKR and C57L. AKR.has the Hba "f" genetic type which specifies only alpha-globin chain 5. C57L has the Hba "a" genetic type that specifies only alpha-globin chain 1. Chains 1 and 5 are identical except for a gly --> ala substitution at position 78. Although one would predict that any recombinant inbred strain resulting from thes,e parents would be homozygous for one of these two alpha-globin types, this is not the case for the AKXL-7 strain. These mice express both alpha-globin chains, with chain 1 present in greater amounts than chain 5. The type of genetic reassortment that has occurred has been ascertained through the use of DNA probes to flanking regions of the two non-allelic or "tandem" alpha-globin 1 genes. Southern blot analysis has revealed that the left and right AKXL-7 alphaglobin gene flanking regions are homologous to regions from different parents. This result indicates that the novel AKXL-7 genotype is the result of a reciprocal recombination event. Further analysis using an intergenic region probe narrowed the region of crossover to approximately 5.2 kb. Using the most distal flanking region probes, chromosome walking was performed to recover probes useful for characterization of three different induced mouse alphathalassemia mutations. Results indicate that in all three cases the deletion spans. at least 45 kb, including both alphaglobin genes and the-embryonic alpha-like x gene.
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    A search for [alpha] and [gamma] globin gene anomalies among SS and SC patient

    Ryan, Robrt Frederick (1987-12)
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    The use of the mouse APRT gene in cultured human cells to study point mutations

    Jarrett, Robert A (1988-08)
    Site-specific mutagenesis, gene transfer, and somatic cell selection have been used to develop a method for the identification of site- and sequence-specific point mutationsinduced in a mammalian cell transgenic system. This method utilizes a mouse adenine phosphoribosyltransferase [APRT] gene containing a specific point mutation in an intronjexon splice recognition sequence, which disrupts mRNA processing and destroys a diagnostic Pst I restriction site. This construct was introduced by cotransfection,with the bacterial n&Qr gene into HTD-114, a non-spontaneously-reverting, Aprt- human fibrosarcoma-derived cell line. The construct s·tudied contains I an A to G transition which is revertible with ethyl methanesulfonate [EMS], a mutagen known to produce G to A transitions in eukaryotes and prokaryotes. Exposing two independently derived cell lines containing the construct to EMS concentrations ranging from 0 to 200 ugjml (corresponding-to 100 to 0.8 percent survival) produced a frequency of reversion to the Aprt+ phenotype of 10-7 to 10-2 .
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    Effects of diamide on human red blood cell membranes

    Meeks, R. Darrell (1980-01)
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