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Novel Peroxisomal Localization of Sirtuin 3 and its Biological ImplicationsPost translational modifications (PTMs) such as phosphorylation, acetylation, ubiquitination, methylation, SUMOylation etc. serve to add another level of complexity and functional diversity to the proteome. These PTMs serve to generate a distinct signal which can then regulate the functionality of the protein harboring one or more of these PTMs and hence ultimately regulating the associated signaling/biological pathway. Some of the ways in which PTMs can bring about the change in the functionality of proteome is by influencing the sub-cellular localization of proteins, protein-protein, protein-DNA, protein-RNA interactions, activity of enzymes, protein turnover, oligomerization of proteins etc. Further, a combination of two or more PTMs can bring about another layer of regulation where presence of a particular combination of PTMs is obligatory to elicit the regulatory message (Yang and Seto 2008a).