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The Zika virus in the United States: A comprehensive reviewBackground: With a series of outbreaks spanning the globe, the Zika virus has transitioned, in a short time, from an obscure virus to a public health emergency. Locally transmitted Zika has reached the United States, leading to increased concern regarding further transmission and the potential impact on public health. Methods: The present study was conducted to examine the propagation and effects of Zika in the United States by reviewing published literature regarding Zika in conjunction with updates from the Centers for Disease Control and Prevention. To gauge the regional response, including prevention and control efforts, interviews were conducted with public health and mosquito control officials. Results: Exposure to Zika may be through vectors, sexual activity with an infected partner, or congenitally to the unborn fetus. Regardless of the mode of transmission, Zika infection may result in serious neurological consequences in adults and especially in fetuses. Conclusions: Prevention of Zika infection is key to successful control of the virus. Vector control and surveillance as well as personal protection from virus exposure are necessary to avoid the potentially devastating effects of the virus. In an effort to prevent further spread, public health authorities are implementing strategies for public education, prevention, and containment.