• Adaptive Cerebral Neovascularization in a Model of Type 2 Diabetes

      Schreihofer, Derek A.; Fagan, Susan C.; Ergul, Adviye; Li, Weiguo; Prakash, Roshini; Kelley-Cobbs, Aisha I.; Ogbi, Safia; Kozak, Anna; El-Remessy, Azza B.; Department of Physiology; et al. (2010-01200)
      OBJECTIVE: The effect of diabetes on neovascularization varies between different organ systems. While excessive angiogenesis complicates diabetic retinopathy, impaired neovascularization contributes to coronary and peripheral complications of diabetes. However, how diabetes influences cerebral neovascularization is not clear. Our aim was to determine diabetes-mediated changes in the cerebrovasculature and its impact on the short-term outcome of cerebral ischemia.
    • ADIPOSE HDAC9 DELETION PROTECT AGAINST DIET INDUCED OBESITY IN MICE THROUGH REGULATING ENERGY EXPENDITURE

      Hassan, Nazeera; Zarzour, Abdalrahman; Department of Biological Sciences; Department of Medicine; College of Allied Health Sciences; Kim, Ha Won; Weintraub, Neal; Augusta University (2019-02-13)
      Our group has previously identified histone deacetylase 9 (HDAC9) as a regulator of adipocyte differentiation, and its expression levels were elevated in diet induced obese (DIO) mice.� We also reported that global HDAC9 deletion protected mice against DIO through promoting beige adipogenesis. Here, we hypothesized that adipose HDAC9 correlate with human obesity similar to murine models, and its deletion is sufficient to protect against DIO. To test this hypothesis we crossed HDAC9 floxed mice with adiponectin-cre mice to generate adipose-specific HDAC9 knockout mice (AdipCre-HDAC9), which exhibited 30% less weight gain when fed high fat diet compared to control despite increased food intake, in association with increased energy combustion & O2 consumption, improved insulin sensitivity and glucose tolerance. However, unlike global HDAC9 deletion, this was not associated with increased beige adipogenesis nor increase in brown adipose tissue function. Interestingly, AdipoCre-HDAC9 mice fed normal chow diet didn�t exhibit altered energy expenditure nor weight differences when compared to littermate controls. These finding suggest that adipose HDAC9 regulate energy expenditure in response to high fat diet and can be a promising therapeutic target to combat obesity.
    • Adjunct Post-Operative Analgesia Following Uncomplicated 3rd Molar Removal

      Benton, Bryan; James, J; Department of Oral and Maxillofacial Surgery (Augusta University Libraries, 2019)
      Extraction of 3rd molars is a routine procedure performed in Oral and Maxillofacial Surgery practices. Postoperative analgesia and recovery is a primary concern for patients undergoing removal of 3rd molars. Uncontrolled postoperative pain has been shown to interfere with quality of life, delay recovery, and even contribute to long term unfavorable sequelae of surgery such as chronic pain. Extraction of 3rd molars is widely performed on an outpatient basis and thus postoperative analgesia is patient directed, often with assistance from narcotic analgesics, NSAIDs, or a combination of these. Prescription drug abuse is a public health crisis in the United States. In 2016, 42,249 persons died of an opioid related drug overdose. Narcotic use following surgical procedures can lead to dependency and addiction. In 2016, new persistent opioid use after surgical procedures was 5.9% - 6.5%, this was similar for both minor and major surgical procedures.
    • Adjuvant Chemotherapy for Patients with Stage III Colon Cancer: Results from a CDC-NPCR Patterns of Care Study.

      Cress, Rosemary D; Sabatino, Susan A; Wu, Xiao-Cheng; Schymura, Maria J; Rycroft, Randi; Stuckart, Erik; Fulton, John; Shen, Tiefu; Department of Health Management and Informatics (2010-08-06)
      OBJECTIVE: To evaluate adjuvant chemotherapy use for Stage III colon cancer. METHODS: This analysis included 973 patients with surgically treated stage III colon cancer. Socioeconomic information from the 2000 census was linked to patients' residential census tracts. Vital status through 12/31/02 was obtained from medical records and linkage to state vital statistics files and the National Death Index. RESULTS: Adjuvant chemotherapy was received by 67%. Treatment varied by state of residence, with Colorado, Rhode Island and New York residents more likely to receive chemotherapy than Louisiana residents. Older age, increasing comorbidities, divorced/widowed marital status, and residence in lower education areas or non-working class neighborhoods were associated with lower chemotherapy use. Survival varied by state but after adjustment for sex, sociodemographic and health factors, was significantly higher only for California and Rhode Island. Older age and lower educational attainment were associated with lower survival. Chemotherapy was protective for all comorbidity groups. CONCLUSION: Although adjuvant chemotherapy for Stage III colon cancer improves survival, some patients did not receive standard of care, demonstrating the need for cancer treatment surveillance. Interstate differences likely resulted from differences in local practice patterns, acceptance of treatment, and access.
    • Adult Type 3 Adenylyl Cyclaseâ Deficient Mice Are Obese

      Wang, Zhenshan; Li, Vicky; Chan, Guy C. K.; Phan, Trongha; Nudelman, Aaron S.; Xia, Zhengui; Storm, Daniel R.; Tsien, Joe Z.; Department of Neurology; College of Graduate Studies (2009-09-11)
      Background: A recent study of obesity in Swedish men found that polymorphisms in the type 3 adenylyl cyclase (AC3) are associated with obesity, suggesting the interesting possibility that AC3 may play a role in weight control. Therefore, we examined the weight of AC3 mice over an extended period of time.
    • Aesthetic improvement of a smile using minimal intervention procedures. A case report

      Cowan, Marcus; Babb, C; Romero, M; Pruett, M; Coleman, J; Department of Restorative Sciences (Augusta University, 2019)
      Tooth discoloration, particularly affecting the maxillary anterior teeth, is often an esthetic concern for dental patients.1 The most common cause of intrinsic tooth discoloration is dental fluorosis (DF),1 which is enamel hypomineralization due to long-term ingestion of high levels of fluoride during tooth mineralization.2 DF results in white opaque areas or discolorations ranging from yellow to dark brown, with porosities on the enamel surface.3 A widely-used scale for classifying the severity of DF is the Tooth Surface Index of Fluorosis (TSIF), developed by Horowitz, by which the examiner determines the extent of affected enamel by estimating the amount of DF as a fraction of the total visible enamel surface.4 Microabrasion, introduced by Croll and Cavanaugh in 1986,5 is a technique used to correct surface enamel irregularities and remove intrinsic enamel stains through the application of hydrochloric acid combined with pumice in a paste.6 When performed correctly and conservatively, the amount of enamel loss from microabrasion is clincally insignificant.7 The success of microabrasion depends upon the extent and severity of the discoloration, and occasionally a slightly yellowish appearance will result from the yellow dentin shade showing through the translucent enamel.8 The final appearance can be improved by dental bleaching, with long-lasting results.7 The following article is a clinical report of the use of microabrasion combined with nightguard bleaching with 10% carbamide peroxide to improve the appearance of teeth affected by fluorosis.
    • Aggression and Competition in Captive Western Lowland Gorillas and Their Wild Counterparts

      Dixon, Megan K.; Department of Biological Sciences (Augusta University, 2015-12)
      Studies of behavior in wild and captive Western Lowland Gorilla (Gorilla gorilla gorilla) populations have exposed patterns of aggressive and affiliative behavior within family groups. Studies such as those of Stokes (2004), Stoinski et al., (2009), Robbins et al., (2004), as well as others have shown the types of situations, dominance patterns, and social dynamics that lead to aggressive and affiliative behaviors between individuals. This study examined the gorillas of Habitat Three, particularly the adult females, housed in Zoo Atlanta to see the types of aggressive behaviors exhibited, the situations they occur in, and the patterns of this population, looking for similarities and differences to observations of wild gorilla populations. Descriptive analyses show noncontact aggression occurs more frequently than contact aggression within this population. Results of one-way analyses of variance (ANOVA) show there is no significant difference in the amount of aggression concerning the conditions of food presence and proximity to the silverback. More data is needed to retest these conditions within Zoo Atlanta’s population. The present paper also compares the behaviors, specifically aggressive and affiliative, of this family group to research regarding wild western lowland gorilla groups.
    • AKAP350 Targets to the Golgi Apparatus Where it Interacts with CLIC5B and CIP4/S

      Shanks, Ryan; Department of Biochemistry and Molecular Biology (2002-03)
      A-kinase anchoring proteins (AKAPs) are defined by their ability to scaffold PKA, but their function depends upon their targeting of PKA and other scaffolded signaling proteins to specific subcellular compartments. We have investigated one AKAP, AKAP350, which can scaffold a number of protein kinases and phosphatases at the centrosome and the Golgi apparatus. The AKAP350 gene is multiply spliced to create three carboxyl terminal splice variants which we have designated AKAP350A, AKAP350B and AKAP350C. Immunocytochemistry in HCA-7 cells demonstrated that AKAP350A was localized specifically to the Golgi apparatus. GFP-fusion proteins representing the carboxyl terminus of AKAP350A identified a carboxyl terminal region responsible for the Golgi apparatus targeting of AKAP350A. Yeast two-hybrid analysis was utilized to screen a rabbit gastric parietal cell library with a 3.2kb segment of AKAP350 (nucleotides 3611-6813) which is weakly homologous to pericentrin. This screen yielded two positive clones representing rabbit chloride intracellular channel 1 (CLIC1) and rabbit Cdc42 interacting protein 5 (CIP5). Further yeast-two hybrid binary analysis determined that CLIC1 and CIP5 bound to AKAP350 through adjacent domains located with in the PHR. CLIC1 belongs to a family of proteins which all contain a high degree of homology in their carboxyl termini, and this conserved domain is responsible for several CLIC family member’s ability to bind AKAP350. We isolated the human homologue of bovine p64, CLIC5B, from an HCA-7 colonic adenocarcinoma cell cDNA. A splice variant of CLIC5, the predicted molecular weight of CLIC5B corresponds to the molecular weight of a major CLIC immunoreactive protein in HCA-7 cells. Immunocytochemistry determined that CLIC5B colocalized with AKAP350 at the Golgi apparatus. Yeast-two hybrid binary analysis determined that the final 120 amino acids of CLIC5B interacted with AKAP350. Furthermore, expression of a GFP-fusion protein containing the final 120 amino acids targeted to the Golgi apparatus in HCA-7 cells. CIP5 contains high homology to the human protein Cdc42 interacting protein 4 (CIP4). Yeast-two hybrid binary analysis determined that the first 117 amino acids of both human CIP4 and CIP5 interacted with AKAP350. Immunocytochemistry in HCA-7 cells determined with an antibody recognizing CIP4 and CIP5 localized to the Golgi apparatus. These results suggest that AKAP350 associates with CLIC proteins and CIP4/5, and these proteins interact with the AKAP35A splice variant at the Golgi apparatus.
    • AKAP350: A Centrosome Associated Scaffold Protein

      Schmidt, Hank; Department of Biochemistry and Molecular Biology (2000-06)
      A-kinase anchoring proteins (AKAPs) are recognized as key components of compartmentalization and transduction in intracellular cAMP signaling. They allow localization of the Type II c AMP-dependent protein kinase to specific subcellular domains, effectively positioning the enzyme near its substrate to await activation by cAMP. The role of AKAPs as protein scaffolds allows binding of multiple enzymes, regulatory molecules, and structural elements, functioning as a virtual platform for modulation of specific cellular events (i.e. membrane channel activity, receptor clustering). We have cloned a novel 350 kDa AKAP (AKAP350) from human gastric cDNA, and identified partial clones in human lung and rabbit parietal cells. The genomic region containing AKAP350, found on chromosome 7q21, is multiply spliced, producing at least three distinct AKAP350 isoforms as well as yotiao, an NMDA receptorassociated protein. We identified three unique AKAP350 C-termini (AKAP350A, -B, and -C) resulting from alternative splicing of the 3' end of the gene. AKAP350 is associated with centrosomes, as well as with the cleavage furrow during anaphase and telophase by immunocytochemistry. Polyclonal antibodies to individual AKAP350 Cterminal splice variants demonstrate tissue dependent combinations of centrosomal and non-centrosomal distribution. In the polarized HCA-7 colon cell line AKAP350A is purely non-centrosomal while AKAP350B and -C are centrosomal. Anti-AKAP350C is limited to mitotic cells, suggesting that this isoform may be expressed only at entry into M phase. A yeast two-hybrid screen of a rabbit parietal cell library identified a novel TACC (Transforming Acidic Coiled coil Containing) protein family member as a ligand of the final pair of arginine residues in the AKAP350A splice variant. A GFP fusion with the novel AKAP interacting protein verified co-localization with AKAP350 at the centrosome exclusively during mitosis. Microinjection of dividing sea urchin embryos with GST fused to the AKAP interacting protein arrested cell division. Therefore, the AKAP350 protein scaffold may function as a large docking station, providing kinase / phosphatase signals for coordination of cytoskeletal dynamics as well as cell division.
    • Alone at Home: Alienation in Ragtime

      Quinton, Rachel; Department of English & Foreign Languages (2017-03)
      This analysis looks at E.L. Doctorow's novel, Ragtime. Throughout the work, Doctorow hints at the blurring of belonging in reality in Pre-World War I America, resulting in alienation. Using a Marxist and Postmodernism lens, this essay focuses on alienation that functions on two levels - the dissociation of the individual from social belonging and through a coercive superstructure of media that separates characters from historical reality. The characters in Ragtime, both in the central family and outside, can identify with at least one level of alienation. By observing the characters through these lenses, it becomes apparent how they are shaped by their alienation. In this context the characters within the novel Ragtime serve as an example of alienation manifested through a dissociation from reality and organized by a coercive media beholden to a capital economic pressure. This observation highlights the value of identity and how the media can affect the way others look at "the reality" behind such identities. It also considers the extent of how media integrates itself into daily life and how this influence is controlled by the base of all society: the economy. Doctorow's book suggests there is a separation of truth from media, and reality from identity.
    • Alterations in Articular Cartilage of the Rabbit Mandibular Condyle Following Surgical Induction of Anterior Disc Displacement: Light and Electron Microscopic Immunocytochemistry Using Colloidal Gold Conjugates

      Choi, Won-Seok; Department of Oral Biology (1996-05)
      The purpose of this study was to test the hypothesis that surgical induction of anterior disc displacement (ADD) in the rabbit craniomandibular joints (CMJ) will lead to degenerative osteoarthritic changes detectable a t the molecular, subcellular and cellular levels in the articular cartilage of the rabbit mandibular condyle. Ultrastructural features of the normal rabbit mandibular condyle were compared to those of experimental condyles a t two weeks following induction of ADD. The quantities of type-VI and -IX collagens, as well as the components of proteoglycans, such as chondroitin-4-sulfate (C4S), chondroitin-6-sulfate (C6S), k e ra tan sulfate (KS) and link protein (LP) were measured using immunogold labeling technique at the light and the electron microscopic levels. The right joint of each of 20 rabbits was exposed surgically, and all discal attachments were severed except for th e posterior attachment. The disc was then displaced anteriorly and sutured to the zygomatic arch. The left joint served as a sham -operated control. Ten additional joints were used as non­ operated controls. Deeply anesthetized rabbits were perfused with 2% buffered formalin two weeks after surgery. The mandibular condyles were excised and decalcified in ethylenediam inetetraacetic acid (EDTA). Paraffin embedded tissues were sectioned a t 5 (im for light microscopic study, while water-soluble plastic embedded sections were used for electron microscopy. Sections were incubated in monoclonal antibodies directed against C4S, C6S, KS and LP, and in polyclonal antibodies against type-VI and -IX collagens. After incubation in the appropriate colloidal gold conjugated secondary antibodies, tissue sections were studied with light and electron microscopes. In addition, immunostaining for proliferating cell nuclear antigen (PCNA) was performed using paraffin sections, and the PCNA indices of control and experimental condyles were determined. Pathological alterations were obvious in the experimental condyles, and appeared to be characteristic osteoarthritic changes. These include cartilage neovascularization, chondrocyte clustering, vacuolation, loss of extracellular matrix next to the membranes of chondrocytes, and an increase in num ber of apoptotic chondrocytes. Increased num bers of PCNA-positive cells in the osteoarthritic cartilage of the experimental group indicated a n active chondrocytic proliferation. Ultrastructural changes in injured chondrocytes included increased amounts of RER and Golgi, suggesting an increase in the synthesis and secretion of possibly degradative enzymes with a decrease in the normal secretory products. The results of th e immunocytochemistry using colloidal gold conjugates both a t the light and electron microscopic levels showed statistically significant depletion of C4S, C6S, KS, LP, type-VI collagen and type-IX collagen in the osteoarthritic cartilage (P < 0.05). The reduction of binding molecules such as LP, type-VI and type-IX collagens suggest a possible mechanism for the observed loss of integrity of the extracellular matrix. It is concluded that surgical induction of ADD in the rabbit CMJ leads to molecular, cellular and extracellular alterations in the articular cartilage of the mandibular condyle similar to those described previously in hum an ADD and in osteoarthritis of other synovial joints. The results of this study provide evidence that the loss of the shock absorber function of the disc, and the exposure of the condyles to overloading may cause the injured chondrocytes to secrete degenerative cytokines as indicated by the loss of proteoglycans, binding collagens and LP. These molecular changes are expressed a t the subcellular and cellular levels as osteoarthritis or degenerative joint disease.
    • Amino acid derivatives are substrates or non-transported inhibitors of the amino acid transporter PAT2 (slc36a2)

      Ganapathy, Vadivel; Department of Biochemistry and Molecular Biology (2011-01)
      The H+-coupled amino acid transporter PAT2 (SLC36A2) transports the amino acids proline, glycine, alanine and hydroxyproline. A physiological role played by PAT2 in amino acid reabsorption in the renal proximal tubule is demonstrated by mutations in SLC36A2 that lead to an iminoglycinuric phenotype (imino acid and glycine uria) in humans. A number of proline, GABA and tryptophan derivatives were examined to determine if they function either as transported substrates or non-transported inhibitors of PAT2. The compounds were investigated following heterologous expression of rat PAT2 in Xenopus laevis oocytes. PAT2 function was characterised by: radiotracer uptake and competition (cis-inhibition) studies; radiotracer efflux and trans-stimulation; and measurement of substrate-induced positive inward current by two-electrode voltage-clamp. In general, the proline derivatives appeared to be transported substrates and the relative ability to induce current flow was closely related to the inhibitory effects on PAT2-mediated
    • Amyloid Peptide-a7 Nicotinic Acetylcholine Receptor Interactions: Implications For Cytoprotection In Vitro

      Li, Xinyu D.; Department of Cellular Biology and Anatomy (2006-11)
      Brain deposition of (3-amyloid peptide 1-42 (A(31 -42)-containing senile plaques has been a consistent finding in Alzheimer’s disease (AD). However, the link between Apl-42 and neuronal degeneration remains unclear. It has been reported that AP peptides bind with selectivity to a l nicotinic acetylcholine receptors (a7nAChRs), in both healthy and Alzheimer’s Diseased brain tissues. The goal of this study was to demonstrate the functional inhibition of oc7nAChRs induced by Api-42, both in systems in vitro and in vivo. Initially, differentiated PC-12 cells were preloaded with fura 2-AM and intracellular free Ca2+ levels were determined by fluorescent imaging. Nicotine-induced Ca2+ signals were inhibited by pretreatment with the a7nAChR-selective antagonists, abungarotoxin (BTX) and methyllycaconitine (MLA). Nicotine induced Ca2+ influx was also blocked by pretreatment with 100 nM Api-42. In the same model, nicotine produced a concentration-dependent increase in cell viability in differentiated PC-12 cells that underwent nerve growth factor (NGF) withdrawal for 24 hr. The cytoprotective action of nicotine was efficiently antagonized by co-treatment with a7nAChR antagonists. A concentration-dependent inhibition of the cytoprotective action of nicotine also was produced by co-treatment with Apl-42 (1-100 nM). Also in differentiated PC-12 cells, nicotine induced a concentration-dependent increase in cell surface Trk A receptor expression. This increase was almost completely reversed by a7receptor-selective antagonists, and by co-treatment with Api-42. In in vivo studies with rats, intracerebroventricular (icv) injection of choline, a selective a7nAChR agonist, produced transient, but dose-dependent pressor responses and prolonged decreases in heart rate. Icv pretreatment with BTX and MLA significantly inhibited the cardiovascular responses to subsequent injection of choline. Pretreatment with the Api-42 also significantly inhibited the choline-induced cardiovascular changes suggesting that the peptide can block an oc7nAChR-mediate response in vivo. Nicotine also was administered to rats by direct injection into a lateral cerebral ventricle. Estimation of Trk A expression in necropsied brain tissues revealed significant increases in hippocampus and entorhinal cortex. These increases were significantly inhibited in rats co-treated with a-bungarotoxin or with Api-42. The data derived from these in vitro and in vivo experiments support the hypothesis that low physiological concentrations of AP peptides inhibit the function of a7nAChRs, thereby contributing to the loss in neuronal viability that accompanies Alzheimer’s disease.
    • An Essential Oil Intervention for Chemotherapy-Induced Peripheral Neuropathy in Breast Cancer Survivors: A Mixed Methods Study

      Langley-Brady, Dawn Louise; Nursing (Augusta University, 2020-12)
      Chemotherapy-induced peripheral neuropathy (CIPN) is a painful, debilitating consequence of cancer treatment and is considered the most adverse of non-hematologic events. Pharmacological approaches to CIPN are often ineffective and cause adverse effects. A problem faced by many breast cancer survivors is poor CIPN treatment coupled with practitioners’ lack of understanding about their subsequent quality-of-life (QOL). Essential oils (EOs) are an underutilized non-pharmacological approach to pain reduction. EO mechanisms of action include non-competing inhibition of 5-HT, AchE, and Substance P and antagonism of TRPA1 and TRPV1. The study aims were to ascertain the effect of an EO intervention (EOI) on CIPN and quality-of-life (QOL) in breast cancer survivors and develop a deeper understanding of CIPN QOL using photovoice methodology. This mixed methods research design employed a randomized, single-blind, placebo-controlled trial. Twenty-six breast cancer survivors with chronic lower extremity CIPN were enrolled in the quantitative strand using purposive sampling. Participants were stratified by baseline pain score and randomized to intervention (n = 13) and placebo (n = 13) groups. Participants topically applied an EOI (containing Curcuma longa, Piper nigrum, Pelargonium asperum, Zingiber officinale, Mentha x piperita, and Rosmarinus officinalis ct. cineole) or placebo three times a day for six weeks. Pain was assessed weekly using the Short-Form McGill Pain Questionnaire-2 (SF-MPQ-2) and daily using the Visual Analogue Scale (VAS). QOL was assessed using the QOL:CIPN20 and QOL Adult Cancer Survivor questionnaires(QLACS) at baseline, midpoint, and endpoint. Data were analyzed in SPSS using generalized estimating equations. Test of model main effects were significant for visit (SF-MPQ-2, p = .000; VAS, p = .008; QLACS Pain subdomain, p = .026), but not for visit*group interaction effects. SF-MPQ-2 and VAS positively correlated with QOL:CIPN20 scores (r = .843, r = .671); however, QOL:CIPN20 model main effects were not significant. The VAS %Δ for intervention and placebo groups was -14.67 and -7.57 respectively. This was not statistically significant, but is clinically important. Regardless of group assignment, pain and QOL improved. The EOI was well-tolerated and demonstrated 50% more pain reduction than placebo. A subset of participants(n = 9) were enrolled in the qualitative strand, received photovoice-related training, and spent four weeks photographing their life with CIPN. Participants participated in photo-interviewing, a photo discussion focus group, a photovoice exhibition at a local art gallery, and an event de-briefing focus group. Data were analyzed in NVivo using thematic, visual content, and iconographical analyses. Six primary themes emerged from the data: (a) advice for clinicians, (b) positive photovoice experience, and CIPN (c) causes pain, (d) affects relationships, (e) causes disruptions, and (f) alters self-image. Further research is needed to enhance EO pain-reducing efficacy as a natural nursing intervention. CIPN greatly impacts breast cancer survivors’ QOL and is multifaceted. Nursing care for breast cancer survivors should include education regarding the potential severity and lifelong effects of CIPN and benefits of study participation and group support.
    • AN EXPLORATION OF ELEMENTARY STUDENTS' PERSPECTIVES ON PARTICIPATING IN A PROSOCIAL BEHAVIOR SUPPORT PROGRAM

      Cason, Natalie Michelle; Department of Advanced Studies and Innovation (Augusta University, 2020-05)
      Children who lack prosocial skills and exhibit social-emotional deficiencies tend to have more behavior problems in school. Chronic behavior problems negatively affect students’ academics, attendance, and ability to develop relationships. Aggression, bullying, and mental health problems have also been linked to social-emotional deficiencies. Children’s prosocial skills and emotional intelligence correlate to children’s social-emotional competence. The researchers investigated students’ perspectives of their experiences with and their perception of the impact a prosocial behavior intervention, Skillstreaming the Elementary School Child (McGinnis & Goldstein, 2012), had on their behavior through focus groups and field observations. Participants were consenting and assenting second through fifth-grade students who were identified through the behavior RTI process in Rural County. Researchers also analyzed quantitative, descriptive data from a Skillstreaming Student Checklist, to investigate how students self-rated their own prosocial skills. The researchers found that the participants were able to identify prosocial skills but did not always choose to apply the prosocial skills they learned to social situations with teachers and peers. All participants communicated positive feelings towards the intervention and liked having the opportunity to escape and process their emotions. Many felt it provided them with tools they could recall and apply to their school settings. Students emphasized the importance of relationships in relation to their behavior, and students interpreted their relationships based on attributes of fairness and care. In discussion of findings, research supported the importance of relationship between teachers and students and supported the finding that students often know prosocial skills and expectations in the school setting but choose their behavior based on the relationship between the student and the teacher. Keywords: prosocial intervention, elementary students, behavioral challenge, school discipline, prosocial skills, emotional intelligence, social-emotional competence, social-emotional learning, RTI, PBIS, Skillstreaming, student perspectives
    • AN EXPLORATION OF ELEMENTARY STUDENTS’ PERSPECTIVES ON PARTICIPATING IN A PROSOCIAL BEHAVIOR SUPPORT PROGRAM

      Aycock, Jeana; Department of Advanced Studies and Innovation (Augusta University, 2020-05)
      Children who lack prosocial skills and exhibit social-emotional deficiencies tend to have more behavior problems in school. Chronic behavior problems negatively affect students’ academics, attendance, and ability to develop relationships. Aggression, bullying, and mental health problems have also been linked to social-emotional deficiencies. Children’s prosocial skills and emotional intelligence correlate to children’s social-emotional competence. The researchers investigated students’ perspectives of their experiences with and their perception of the impact a prosocial behavior intervention, Skillstreaming the Elementary School Child (McGinnis & Goldstein, 2012), had on their behavior through focus groups and field observations. Participants were consenting and assenting second through fifth-grade students who were identified through the behavior RTI process in Rural County. Researchers also analyzed quantitative, descriptive data from a Skillstreaming Student Checklist, to investigate how students self-rated their own prosocial skills. The researchers found that the participants were able to identify prosocial skills but did not always choose to apply the prosocial skills they learned to social situations with teachers and peers. All participants communicated positive feelings towards the intervention and liked having the opportunity to escape and process their emotions. Many felt it provided them with tools they could recall and apply to their school settings. Students emphasized the importance of relationships in relation to their behavior, and students interpreted their relationships based on attributes of fairness and care. In discussion of findings, research supported the importance of relationship between teachers and students and supported the finding that students often know prosocial skills and expectations in the school setting but choose their behavior based on the relationship between the student and the teacher. Keywords: prosocial intervention, elementary students, behavioral challenge, school discipline, prosocial skills, emotional intelligence, social-emotional competence, social-emotional learning, RTI, PBIS, Skillstreaming, student perspectives
    • AN EXPLORATION OF ELEMENTARY STUDENTS’ PERSPECTIVES ON PARTICIPATING IN A PROSOCIAL BEHAVIOR SUPPORT PROGRAM

      Ocak, Lauren A. W.; Department of Advanced Studies and Innovation (Augusta University, 2020-05)
      Children who lack prosocial skills and exhibit social-emotional deficiencies tend to have more behavior problems in school. Chronic behavior problems negatively affect students’ academics, attendance, and ability to develop relationships. Aggression, bullying, and mental health problems have also been linked to social-emotional deficiencies. Children’s prosocial skills and emotional intelligence correlate to children’s social-emotional competence. The researchers investigated students’ perspectives of their experiences with and their perception of the impact a prosocial behavior intervention, Skillstreaming the Elementary School Child (McGinnis & Goldstein, 2012), had on their behavior through focus groups and field observations. Participants were consenting and assenting second through fifth-grade students who were identified through the behavior RTI process in Rural County. Researchers also analyzed quantitative, descriptive data from a Skillstreaming Student Checklist, to investigate how students self-rated their own prosocial skills. The researchers found that the participants were able to identify prosocial skills but did not always choose to apply the prosocial skills they learned to social situations with teachers and peers. All participants communicated positive feelings towards the intervention and liked having the opportunity to escape and process their emotions. Many felt it provided them with tools they could recall and apply to their school settings. Students emphasized the importance of relationships in relation to their behavior, and students interpreted their relationships based on attributes of fairness and care. In discussion of findings, research supported the importance of relationship between teachers and students and supported the finding that students often know prosocial skills and expectations in the school setting but choose their behavior based on the relationship between the student and the teacher. Keywords: prosocial intervention, elementary students, behavioral challenge, school discipline, prosocial skills, emotional intelligence, social-emotional competence, social-emotional learning, RTI, PBIS, Skillstreaming, student perspectives
    • AN EXPLORATION OF ELEMENTARY STUDENTS’ PERSPECTIVES ON PARTICIPATING IN A PROSOCIAL BEHAVIOR SUPPORT PROGRAM

      Lott, Joe Henry; Department of Advanced Studies and Innovation (Augusta University, 2020-05)
      Children who lack prosocial skills and exhibit social-emotional deficiencies tend to have more behavior problems in school. Chronic behavior problems negatively affect students’ academics, attendance, and ability to develop relationships. Aggression, bullying, and mental health problems have also been linked to social-emotional deficiencies. Children’s prosocial skills and emotional intelligence correlate to children’s social-emotional competence. The researchers investigated students’ perspectives of their experiences with and their perception of the impact a prosocial behavior intervention, Skillstreaming the Elementary School Child (McGinnis & Goldstein, 2012), had on their behavior through focus groups and field observations. Participants were consenting and assenting second through fifth-grade students who were identified through the behavior RTI process in Rural County. Researchers also analyzed quantitative, descriptive data from a Skillstreaming Student Checklist, to investigate how students self-rated their own prosocial skills. The researchers found that the participants were able to identify prosocial skills but did not always choose to apply the prosocial skills they learned to social situations with teachers and peers. All participants communicated positive feelings towards the intervention and liked having the opportunity to escape and process their emotions. Many felt it provided them with tools they could recall and apply to their school settings. Students emphasized the importance of relationships in relation to their behavior, and students interpreted their relationships based on attributes of fairness and care. In discussion of findings, research supported the importance of relationship between teachers and students and supported the finding that students often know prosocial skills and expectations in the school setting but choose their behavior based on the relationship between the student and the teacher.