• Genistein attenuates retinal inflammation associated with diabetes by targeting of microglial activation

      Ibrahim, Ahmed S.; El-Shishtawy, Mamdouh M.; Pena, Alejandro Jr.; Liou, Gregory I.; Department of Ophthalmology; Department of Medicine (2010-10-08)
      Purpose: Diabetic retinopathy (DR) is associated with microglial activation and increased levels of inflammatory cytokines. Genistein, a tyrosine kinase inhibitor, has been shown to possess anti-inflammatory potential that so far untested in animal models of diabetes. The aims of this study are to evaluate the efficacy of genistein for alleviation of diabetes-induced retinal inflammation and also to gain insight into the molecular mechanisms involved therein by analyzing the effect of genistein on concomitant microglia activation in the diabetic retina and in isolated cells.