• Behavioral Consequences of NMDA Antagonist-Induced Neuroapoptosis in the Infant Mouse Brain

      Yuede, Carla M.; Wozniak, David F.; Creeley, Catherine E.; Taylor, George T.; Olney, John W.; Farber, Nuri B.; Mei, Lin; Department of Neurology (2010-06-29)
      Background: Exposure to NMDA glutamate antagonists during the brain growth spurt period causes widespread neuroapoptosis in the rodent brain. This period in rodents occurs during the first two weeks after birth, and corresponds to the third trimester of pregnancy and several years after birth in humans. The developing human brain may be exposed to NMDA antagonists through drug-abusing mothers or through anesthesia.