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    Parkinson's disease-related protein, alpha-synuclein, in malignant melanoma.

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    Authors
    Matsuo, Yasuhiro
    Kamitani, Tetsu
    Issue Date
    2010-05-13
    URI
    http://hdl.handle.net/10675.2/28
    
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    Abstract
    BACKGROUND: Melanoma is the major cause of skin cancer death worldwide. Parkinson's disease is a neurodegenerative disorder that is caused by mutation of alpha-synuclein or other genes. Importantly, epidemiological studies have reported co-occurrence of melanoma and Parkinson's disease, suggesting that these two diseases could share common genetic components. METHODOLOGY/PRINCIPAL FINDINGS: Recently, we found that human melanoma cell lines highly express alpha-synuclein, whereas the protein is undetectable in the non-melanoma cancer cell lines tested. To investigate the expression of alpha-synuclein in human melanoma tissues, we immunostained sections of melanoma, nevus, non-melanocytic cutaneous carcinoma, and normal skin. alpha-Synuclein was positively detected in 86% of the primary and 85% of the metastatic melanoma sections, as well as in 89% of nevus sections. However, alpha-synuclein was undetectable in non-melanocytic cutaneous carcinoma and normal skin. CONCLUSIONS/SIGNIFICANCE: The Parkinson's disease-related protein, alpha-synuclein, is expressed in both malignant and benign melanocytic lesions, such as melanomas and nevi. Although alpha-synuclein cannot be used to distinguish between malignant and benign melanocytic skin lesions, it might be a useful biomarker for the diagnosis of metastatic melanoma.
    Citation
    PLoS One. 2010 May 5; 5(5):e10481
    ae974a485f413a2113503eed53cd6c53
    10.1371/journal.pone.0010481
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    Center for Molecular Chaperone/Radiobiology & Cancer Virology: Faculty Research and Presentations

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