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    Genetic and Molecular Basis of QTL of Diabetes in Mouse: Genes and Polymorphisms.

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    Authors
    Gao, Peng
    Jiao, Yan
    Xiong, Qing
    Wang, Cong-Yi
    Gerling, Ivan
    Gu, Weikuan
    Issue Date
    2009-05-27
    URI
    http://hdl.handle.net/10675.2/16
    
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    Abstract
    A systematic study has been conducted of all available reports in PubMed and OMIM (Online Mendelian Inheritance in Man) to examine the genetic and molecular basis of quantitative genetic loci (QTL) of diabetes with the main focus on genes and polymorphisms. The major question is, What can the QTL tell us? Specifically, we want to know whether those genome regions differ from other regions in terms of genes relevant to diabetes. Which genes are within those QTL regions, and, among them, which genes have already been linked to diabetes? whether more polymorphisms have been associated with diabetes in the QTL regions than in the non-QTL regions.Our search revealed a total of 9038 genes from 26 type 1 diabetes QTL, which cover 667,096,006 bp of the mouse genomic sequence. On one hand, a large number of candidate genes are in each of these QTL; on the other hand, we found that some obvious candidate genes of QTL have not yet been investigated. Thus, the comprehensive search of candidate genes for known QTL may provide unexpected benefit for identifying QTL genes for diabetes.
    Citation
    Curr Genomics. 2008 Aug; 9(5):324-337
    ae974a485f413a2113503eed53cd6c53
    10.2174/138920208785133253
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