• Login
    View Item 
    •   Home
    • Centers & Institutes
    • Brain & Behavior Discovery Institute
    • Brain & Behavior Discovery Institute: Faculty Research and Presentations
    • View Item
    •   Home
    • Centers & Institutes
    • Brain & Behavior Discovery Institute
    • Brain & Behavior Discovery Institute: Faculty Research and Presentations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of Scholarly CommonsCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    About

    AboutCreative CommonsAugusta University LibrariesUSG Copyright Policy

    Statistics

    Display statistics

    Conditional knockout of NMDA receptors in dopamine neurons prevents nicotine-conditioned place preference.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    pone.0008616.pdf
    Size:
    418.6Kb
    Format:
    PDF
    Download
    Authors
    Wang, Lei Phillip
    Li, Fei
    Shen, Xiaoming
    Tsien, Joe Z.
    Issue Date
    2010-01-11
    URI
    http://hdl.handle.net/10675.2/156
    
    Metadata
    Show full item record
    Abstract
    Nicotine from smoking tobacco produces one of the most common forms of addictive behavior and has major societal and health consequences. It is known that nicotine triggers tobacco addiction by activating nicotine acetylcholine receptors (nAChRs) in the midbrain dopaminergic reward system, primarily via the ventral tegmental area. Heterogeneity of cell populations in the region has made it difficult for pharmacology-based analyses to precisely assess the functional significance of glutamatergic inputs to dopamine neurons in nicotine addiction. By generating dopamine neuron-specific NR1 knockout mice using cre/loxP-mediated method, we demonstrate that genetic inactivation of the NMDA receptors in ventral tegmental area dopamine neurons selectively prevents nicotine-conditioned place preference. Interestingly, the mutant mice exhibit normal performances in the conditioned place aversion induced by aversive air puffs. Therefore, this selective effect on addictive drug-induced reinforcement behavior suggests that NMDA receptors in the dopamine neurons are critical for the development of nicotine addiction.
    Citation
    PLoS One. 2010 Jan 7; 5(1):e8616
    ae974a485f413a2113503eed53cd6c53
    10.1371/journal.pone.0008616
    Scopus Count
    Collections
    Brain & Behavior Discovery Institute: Faculty Research and Presentations

    entitlement

    Related articles

    • NMDA Receptors on Dopaminoceptive Neurons Are Essential for Drug-Induced Conditioned Place Preference.
    • Authors: Sikora M, Tokarski K, Bobula B, Zajdel J, Jastrzębska K, Cieślak PE, Zygmunt M, Sowa J, Smutek M, Kamińska K, Gołembiowska K, Engblom D, Hess G, Przewlocki R, Rodriguez Parkitna J
    • Issue date: 2016 May-Jun
    • Why flavored vape products may be attractive: Green apple tobacco flavor elicits reward-related behavior, upregulates nAChRs on VTA dopamine neurons, and alters midbrain dopamine and GABA neuron function.
    • Authors: Avelar AJ, Akers AT, Baumgard ZJ, Cooper SY, Casinelli GP, Henderson BJ
    • Issue date: 2019 Nov 1
    • Menthol Alone Upregulates Midbrain nAChRs, Alters nAChR Subtype Stoichiometry, Alters Dopamine Neuron Firing Frequency, and Prevents Nicotine Reward.
    • Authors: Henderson BJ, Wall TR, Henley BM, Kim CH, Nichols WA, Moaddel R, Xiao C, Lester HA
    • Issue date: 2016 Mar 9
    • Differential desensitization and distribution of nicotinic acetylcholine receptor subtypes in midbrain dopamine areas.
    • Authors: Wooltorton JR, Pidoplichko VI, Broide RS, Dani JA
    • Issue date: 2003 Apr 15
    • α6-Containing nicotinic acetylcholine receptors in midbrain dopamine neurons are poised to govern dopamine-mediated behaviors and synaptic plasticity.
    • Authors: Berry JN, Engle SE, McIntosh JM, Drenan RM
    • Issue date: 2015 Sep 24
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.