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    Sodium-coupled monocarboxylate transporters in normal tissues and in cancer.

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    Authors
    Ganapathy, Vadivel
    Thangaraju, Muthusamy
    Gopal, Elangovan
    Martin, Pamela M
    Itagaki, Shiro
    Miyauchi, Seiji
    Prasad, Puttur D
    Issue Date
    2008-04-30
    URI
    http://hdl.handle.net/10675.2/133
    
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    Abstract
    SLC5A8 and SLC5A12 are sodium-coupled monocarboxylate transporters (SMCTs), the former being a high-affinity type and the latter a low-affinity type. Both transport a variety of monocarboxylates in a Na(+)-coupled manner. They are expressed in the gastrointestinal tract, kidney, thyroid, brain, and retina. SLC5A8 is localized to the apical membrane of epithelial cells lining the intestinal tract and proximal tubule. In the brain and retina, its expression is restricted to neurons and the retinal pigment epithelium. The physiologic functions of SLC5A8 include absorption of short-chain fatty acids in the colon and small intestine, reabsorption of lactate and pyruvate in the kidney, and cellular uptake of lactate and ketone bodies in neurons. It also transports the B-complex vitamin nicotinate. SLC5A12 is also localized to the apical membrane of epithelial cells lining the intestinal tract and proximal tubule. In the brain and retina, its expression is restricted to astrocytes and M?�ller cells. SLC5A8 also functions as a tumor suppressor; its expression is silenced in tumors of colon, thyroid, stomach, kidney, and brain. The tumor-suppressive function is related to its ability to mediate concentrative uptake of butyrate, propionate, and pyruvate, all of which are inhibitors of histone deacetylases. SLC5A8 can also transport a variety of pharmacologically relevant monocarboxylates, including salicylates, benzoate, and gamma-hydroxybutyrate. Non-steroidal anti-inflammatory drugs such as ibuprofen, ketoprofen, and fenoprofen, also interact with SLC5A8. These drugs are not transportable substrates for SLC5A8, but instead function as blockers of the transporter. Relatively less is known on the role of SLC5A12 in drug transport.
    Citation
    AAPS J. 2008 Apr 2; 10(1):193-199
    ae974a485f413a2113503eed53cd6c53
    10.1208/s12248-008-9022-y
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    Department of Biochemistry and Molecular Biology: Faculty Research and Presentations

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