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    TRPM8 mechanism of autonomic nerve response to cold in respiratory airway.

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    Authors
    Xing, Hong
    Ling, Jennifer X
    Chen, Meng
    Johnson, Richard D
    Tominaga, Makoto
    Wang, Cong-Yi
    Gu, Jianguo
    Issue Date
    2008-06-18
    URI
    http://hdl.handle.net/10675.2/13
    
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    Abstract
    Breathing cold air without proper temperature exchange can induce strong respiratory autonomic responses including cough, airway constriction and mucosal secretion, and can exacerbate existing asthma conditions and even directly trigger an asthma attack. Vagal afferent fiber is thought to be involved in the cold-induced respiratory responses through autonomic nerve reflex. However, molecular mechanisms by which vagal afferent fibers are excited by cold remain unknown. Using retrograde labeling, immunostaining, calcium imaging, and electrophysiological recordings, here we show that a subpopulation of airway vagal afferent nerves express TRPM8 receptors and that activation of TRPM8 receptors by cold excites these airway autonomic nerves. Thus activation of TRPM8 receptors may provoke autonomic nerve reflex to increase airway resistance. This putative autonomic response may be associated with cold-induced exacerbation of asthma and other pulmonary disorders, making TRPM8 receptors a possible target for prevention of cold-associated respiratory disorders.
    Citation
    Mol Pain. 2008 Jun 5; 4:22
    ae974a485f413a2113503eed53cd6c53
    10.1186/1744-8069-4-22
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    Center for Biotechnology and Genomic Medicine: Faculty Research and Presentations

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