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dc.contributor.authorRigsby, Christiné Spring
dc.contributor.authorPollock, David M
dc.contributor.authorDorrance, Anne M
dc.date.accessioned2010-09-24T22:03:23Z
dc.date.available2010-09-24T22:03:23Z
dc.date.issued2008-03-11en_US
dc.identifier.citationNutr Metab (Lond). 2008 Jan 31; 5:3en_US
dc.identifier.issn1743-7075en_US
dc.identifier.pmid18237391en_US
dc.identifier.doi10.1186/1743-7075-5-3en_US
dc.identifier.urihttp://hdl.handle.net/10675.2/122
dc.description.abstractABSTRACT: BACKGROUND: Dietary potassium supplementation in hypertensive rats is cardioprotective. This protection includes a blood pressure independent reduction in the amount of damage caused by cerebral ischemia. Therefore, we hypothesized that dietary potassium supplementation would improve the outcome of ischemic stroke by improving cerebral vessel structure in normotensive rats. METHODS: Wistar Kyoto (WKY) rats were fed a high (HK) or low potassium (LK) diet for six weeks from six weeks of age. At the end of treatment, cerebral ischemia was induced by middle cerebral artery (MCA) occlusion and the resultant infarct was quantified and expressed as a percentage of the hemisphere infarcted (%HI). MCA structure was assessed in an additional group of rats using a pressurized arteriograph. RESULTS: The cerebral infarct was significantly smaller in rats fed the HK diet, compared to rats fed the LK diet (21 +/- 5.4 vs 33.5 +/- 4.8 %HI HK vs LK p < 0.05). Vessel structure was improved in WKY rats fed the HK diet as indicated by an increase in the MCA lumen (298 +/- 6.3 vs 276 +/- 3.9 mum HK vs LK p < 0.05) and outer diameters (322 +/- 7.6 vs 305 +/- 4.8 mum HK vs LK p < 0.05). Wall thickness and area were unchanged, suggesting an outward euthrophic remodelling process. The HK diet had no effect on body weight or telemetry blood pressure. CONCLUSION: These studies are the first to show a beneficial effect of dietary potassium in rats with normal blood pressure.
dc.rightsThe PMC Open Access Subset is a relatively small part of the total collection of articles in PMC. Articles in the PMC Open Access Subset are still protected by copyright, but are made available under a Creative Commons or similar license that generally allows more liberal redistribution and reuse than a traditional copyrighted work. Please refer to the license statement in each article for specific terms of use. The license terms are not identical for all articles in this subset.en_US
dc.titleDietary potassium supplementation improves vascular structure and ameliorates the damage caused by cerebral ischemia in normotensive rats.en_US
dc.typeJournal Articleen_US
dc.identifier.pmcidPMC2266758en_US
dc.contributor.corporatenameDepartment of Physiologyen_US
dc.contributor.corporatenameVascular Biology Centeren_US
refterms.dateFOA2019-04-09T16:24:43Z
html.description.abstractABSTRACT: BACKGROUND: Dietary potassium supplementation in hypertensive rats is cardioprotective. This protection includes a blood pressure independent reduction in the amount of damage caused by cerebral ischemia. Therefore, we hypothesized that dietary potassium supplementation would improve the outcome of ischemic stroke by improving cerebral vessel structure in normotensive rats. METHODS: Wistar Kyoto (WKY) rats were fed a high (HK) or low potassium (LK) diet for six weeks from six weeks of age. At the end of treatment, cerebral ischemia was induced by middle cerebral artery (MCA) occlusion and the resultant infarct was quantified and expressed as a percentage of the hemisphere infarcted (%HI). MCA structure was assessed in an additional group of rats using a pressurized arteriograph. RESULTS: The cerebral infarct was significantly smaller in rats fed the HK diet, compared to rats fed the LK diet (21 +/- 5.4 vs 33.5 +/- 4.8 %HI HK vs LK p < 0.05). Vessel structure was improved in WKY rats fed the HK diet as indicated by an increase in the MCA lumen (298 +/- 6.3 vs 276 +/- 3.9 mum HK vs LK p < 0.05) and outer diameters (322 +/- 7.6 vs 305 +/- 4.8 mum HK vs LK p < 0.05). Wall thickness and area were unchanged, suggesting an outward euthrophic remodelling process. The HK diet had no effect on body weight or telemetry blood pressure. CONCLUSION: These studies are the first to show a beneficial effect of dietary potassium in rats with normal blood pressure.


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