Department of Ophthalmology: Faculty Research and Presentations
http://hdl.handle.net/10675.2/846
2024-03-29T06:36:49ZInactivation of Endothelial ADAM17 Reduces Retinal Ischemia-Reperfusion Induced Neurovascular Abnormalities
http://hdl.handle.net/10675.2/623159
Inactivation of Endothelial ADAM17 Reduces Retinal Ischemia-Reperfusion Induced Neurovascular Abnormalities
Gutsaeva, Diana; Lamiaa, Shalaby; Wetzstein, Sara; Thounaojam, Menaka; Jadeja, Ravirajsinh; Powell, Folami; Martin, Pamela; Kwok, Hang Fai; Bartoli, Manuela
Retinal ischemia contributes to visual impairment in ischemic retinopathies such as diabetic
retinopathy and other potentially blinding conditions. A member of the ADAM family of a disintegrin and
metalloproteinases, ADAM17, contributes to multiple vascular pathologies through its ability to regulate
inflammatory signals via ectodomain shedding. Here we investigated the specific contribution of endothelial
ADAM17 to neurovascular damage associated with retinal ischemia using a mouse model of ischemiareperfusion (IR) injury.
Identification of Regulatory Elements in a Conserved Upstream Region of the Gene Encoding Interphotoreceptor Retinoid-Binding Protein (IRBP)
http://hdl.handle.net/10675.2/550457
Identification of Regulatory Elements in a Conserved Upstream Region of the Gene Encoding Interphotoreceptor Retinoid-Binding Protein (IRBP)
Lu, Haiyan
(First Paragraph) IRBP is a large, single-subunit extracellular glycolipoprotein found in the interphotoreceptor matrix between the photoreceptor cells and retinal pigment epithelium cell layer (Fig. 1.). The protein is synthesized and secreted by the photoreceptor rods and cones, as well as pinealocytes, of all vertebrates. The molecular weight of human IRBP (1230 residues) is 133,400 daltons. This protein consists of four homologous segments of approximately 300 residues each. Each segment contains highly conserved hydrophobic domains among species. Ligands identified as bound to IRBP include retinoid isomers and fatty acids, and IRBP can also bind cholesterol, a-tocopherol and retinoic acid. The ability of IRBP to bind various retinoid isomers, fatty acids and many other hydrophobic ligands suggests multiple functions in the retina .
1999-06-01T00:00:00ZObject recognition in clutter: cortical responses depend on the type of learning
http://hdl.handle.net/10675.2/800
Object recognition in clutter: cortical responses depend on the type of learning
Hegéd, Jay; Thompson, Serena K.; Brady, Mark; Kersten, Daniel
Theoretical studies suggest that the visual system uses prior knowledge of visual objects to recognize them in visual clutter, and posit that the strategies for recognizing objects in clutter may differ depending on whether or not the object was learned in clutter to begin with. We tested this hypothesis using functional magnetic resonance imaging (fMRI) of human subjects. We trained subjects to recognize naturalistic, yet novel objects in strong or weak clutter. We then tested subjects' recognition performance for both sets of objects in strong clutter. We found many brain regions that were differentially responsive to objects during object recognition depending on whether they were learned in strong or weak clutter. In particular, the responses of the left fusiform gyrus (FG) reliably reflected, on a trial-to-trial basis, subjects' object recognition performance for objects learned in the presence of strong clutter. These results indicate that the visual system does not use a single, general-purpose mechanism to cope with clutter. Instead, there are two distinct spatial patterns of activation whose responses are attributable not to the visual context in which the objects were seen, but to the context in which the objects were learned.
2012-06-19T00:00:00ZNodular Fasciitis of the Orbit: A Case Report and Brief Review of the Literature
http://hdl.handle.net/10675.2/789
Nodular Fasciitis of the Orbit: A Case Report and Brief Review of the Literature
Riffle, John E.; Prosser, Andrea H.; Lee, Jeffrey R.; Lynn, Julie J.
Nodular fasciitis is a benign, reactive, fibroblastic proliferation in which nodules most commonly develop in the subcutaneous or superficial fascia of the extremities. The occurrence of these growths in the orbital region is relatively rare. Our intent is to report another orbital case of this benign fibroproliferative tumor and to provide a brief review of the pertinent medical literature. The salient pathologic features of nodular fasciitis are summarized. The potential for the misdiagnosis of these benign mesenchymal tumors as a malignant sarcomatous neoplasm is discussed. It is important for ophthalmologists to be aware of this pathologic entity and its pseudosarcomatous appearance.
2011-10-19T00:00:00Z