Synergistic Enhancement of Sickle Red Blood Cell Adhesion to Endothelium by Hypoxia and Low Nitric Oxide Bioavailability

Hdl Handle:
http://hdl.handle.net/10675.2/938
Title:
Synergistic Enhancement of Sickle Red Blood Cell Adhesion to Endothelium by Hypoxia and Low Nitric Oxide Bioavailability
Authors:
Gutsaeva, Diana R.; Parkerson, James B.; Yerigenahally, Shobha D; Ikuta, Tohru; Head, C. Alvin
Abstract:
The mechanisms underlying sickle red blood cell (RBC) adhesion to the endothelium, which constitutes a major pathologic event in sickle cell disease (SCD), are not fully understood. Adhesion of sickle RBCs to endothelial cells is believed to be regulated by multiple hematologic and physiologic factors including fetal hemoglobin levels, leukocyte count, oxygen tension, inflammatory cytokines, and nitric oxide (NO) bioavailability, but the extent to which each parameter contributes to sickle RBC adhesion remains unclear. Our objective was to examine how the adhesion of sickle RBCs to endothelium is affected by hypoxia and NO bioavailability using an in vivo system.
Publisher:
American Society of Hematology
Issue Date:
Dec-2010
URI:
http://hdl.handle.net/10675.2/938
Language:
en_US
Series/Report no.:
ASH;2010-H01
Appears in Collections:
Department of Anesthesiology and Perioperative Medicine: Faculty Research and Presentaions

Full metadata record

DC FieldValue Language
dc.contributor.authorGutsaeva, Diana R.-
dc.contributor.authorParkerson, James B.-
dc.contributor.authorYerigenahally, Shobha D-
dc.contributor.authorIkuta, Tohru-
dc.contributor.authorHead, C. Alvin-
dc.date.accessioned2013-02-18T23:40:32Z-
dc.date.available2013-02-18T23:40:32Z-
dc.date.issued2010-12-
dc.identifier.urihttp://hdl.handle.net/10675.2/938-
dc.description.abstractThe mechanisms underlying sickle red blood cell (RBC) adhesion to the endothelium, which constitutes a major pathologic event in sickle cell disease (SCD), are not fully understood. Adhesion of sickle RBCs to endothelial cells is believed to be regulated by multiple hematologic and physiologic factors including fetal hemoglobin levels, leukocyte count, oxygen tension, inflammatory cytokines, and nitric oxide (NO) bioavailability, but the extent to which each parameter contributes to sickle RBC adhesion remains unclear. Our objective was to examine how the adhesion of sickle RBCs to endothelium is affected by hypoxia and NO bioavailability using an in vivo system.en_US
dc.language.isoen_USen_US
dc.publisherAmerican Society of Hematologyen_US
dc.relation.ispartofseriesASH;2010-H01-
dc.subjectSickle cell diseaseen_US
dc.subjectHypoxiaen_US
dc.subjectNitric oxideen_US
dc.titleSynergistic Enhancement of Sickle Red Blood Cell Adhesion to Endothelium by Hypoxia and Low Nitric Oxide Bioavailabilityen_US
dc.contributor.corporatenameDepartment of Anesthesiology and Perioperative Medicineen_US
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