Impact of FTO genotypes on BMI and weight in polycystic ovary syndrome: a systematic review and meta-analysis

Hdl Handle:
http://hdl.handle.net/10675.2/826
Title:
Impact of FTO genotypes on BMI and weight in polycystic ovary syndrome: a systematic review and meta-analysis
Authors:
Wojciechowski, P.; Lipowska, A.; Rys, P.; Ewens, Kathryn G.; Franks, Stephen ( 0000-0002-3712-0335 ) ; Tan, S.; Lerchbaum, E.; Vcelak, J.; Attaoua, R.; Straczkowski, M.; Azziz, Ricardo ( 0000-0002-3917-0483 ) ; Barber, T. M.; Hinney, Anke ( 0000-0001-5659-0706 ) ; Obermayer-Pietsch, B.; Lukasova, P.; Bendlova, B.; Grigorescu, F.; Kowalska, I.; Goodarzi, M. O.; Strauss, J. F.; McCarthy, M. I.; Malecki, M. T.
Abstract:
Aims/hypothesis: FTO gene single nucleotide polymorphisms (SNPs) have been shown to be associated with obesity-related traits and type 2 diabetes. Several small studies have suggested a greater than expected effect of the FTO rs9939609 SNP on weight in polycystic ovary syndrome (PCOS). We therefore aimed to examine the impact of FTO genotype on BMI and weight in PCOS.; Methods: A systematic search of medical databases (PubMed, EMBASE and Cochrane CENTRAL) was conducted up to the end of April 2011. Seven studies describing eight distinct PCOS cohorts were retrieved; seven were genotyped for SNP rs9939609 and one for SNP rs1421085. The per allele effect on BMI and body weight increase was calculated and subjected to meta-analysis.; Results: A total of 2,548 women with PCOS were included in the study; 762 were TT homozygotes, 1,253 had an AT/CT genotype, and 533 were AA/CC homozygotes. Each additional copy of the effect allele (A/C) increased the BMI by a mean of 0.19 z score units (95% CI 0.13, 0.24; pâ =â 2.26â à â 10â 11) and body weight by a mean of 0.20 z score units (95% CI 0.14, 0.26; pâ =â 1.02â à â 10â 10). This translated into an approximately 3.3 kg/m2 increase in BMI and an approximately 9.6 kg gain in body weight between TT and AA/CC homozygotes. The association between FTO genotypes and BMI was stronger in the cohorts with PCOS than in the general female populations from large genome-wide association studies. Deviation from an additive genetic model was observed in heavier populations.; Conclusions/interpretation: The effect of FTO SNPs on obesity-related traits in PCOS seems to be more than two times greater than the effect found in large population-based studies. This suggests an interaction between FTO and the metabolic context or polygenic background of PCOS.; Keywords: BMI
Citation:
Diabetologia. 2012 Oct 18; 55(10):2636-2645
Issue Date:
18-Oct-2012
URI:
http://hdl.handle.net/10675.2/826
DOI:
10.1007/s00125-012-2638-6
PubMed ID:
22801903
PubMed Central ID:
PMC3433670
Type:
Article
ISSN:
1432-0428
Appears in Collections:
Department of Obstetrics and Gynecology: Faculty Research and Presentations

Full metadata record

DC FieldValue Language
dc.contributor.authorWojciechowski, P.en_US
dc.contributor.authorLipowska, A.en_US
dc.contributor.authorRys, P.en_US
dc.contributor.authorEwens, Kathryn G.en_US
dc.contributor.authorFranks, Stephenen_US
dc.contributor.authorTan, S.en_US
dc.contributor.authorLerchbaum, E.en_US
dc.contributor.authorVcelak, J.en_US
dc.contributor.authorAttaoua, R.en_US
dc.contributor.authorStraczkowski, M.en_US
dc.contributor.authorAzziz, Ricardoen_US
dc.contributor.authorBarber, T. M.en_US
dc.contributor.authorHinney, Ankeen_US
dc.contributor.authorObermayer-Pietsch, B.en_US
dc.contributor.authorLukasova, P.en_US
dc.contributor.authorBendlova, B.en_US
dc.contributor.authorGrigorescu, F.en_US
dc.contributor.authorKowalska, I.en_US
dc.contributor.authorGoodarzi, M. O.en_US
dc.contributor.authorStrauss, J. F.en_US
dc.contributor.authorMcCarthy, M. I.en_US
dc.contributor.authorMalecki, M. T.en_US
dc.date.accessioned2012-10-26T20:35:12Z-
dc.date.available2012-10-26T20:35:12Z-
dc.date.issued2012-10-18en_US
dc.identifier.citationDiabetologia. 2012 Oct 18; 55(10):2636-2645en_US
dc.identifier.issn1432-0428en_US
dc.identifier.pmid22801903en_US
dc.identifier.doi10.1007/s00125-012-2638-6en_US
dc.identifier.urihttp://hdl.handle.net/10675.2/826-
dc.description.abstractAims/hypothesis: FTO gene single nucleotide polymorphisms (SNPs) have been shown to be associated with obesity-related traits and type 2 diabetes. Several small studies have suggested a greater than expected effect of the FTO rs9939609 SNP on weight in polycystic ovary syndrome (PCOS). We therefore aimed to examine the impact of FTO genotype on BMI and weight in PCOS.en_US
dc.description.abstractMethods: A systematic search of medical databases (PubMed, EMBASE and Cochrane CENTRAL) was conducted up to the end of April 2011. Seven studies describing eight distinct PCOS cohorts were retrieved; seven were genotyped for SNP rs9939609 and one for SNP rs1421085. The per allele effect on BMI and body weight increase was calculated and subjected to meta-analysis.en_US
dc.description.abstractResults: A total of 2,548 women with PCOS were included in the study; 762 were TT homozygotes, 1,253 had an AT/CT genotype, and 533 were AA/CC homozygotes. Each additional copy of the effect allele (A/C) increased the BMI by a mean of 0.19 z score units (95% CI 0.13, 0.24; pâ =â 2.26â à â 10â 11) and body weight by a mean of 0.20 z score units (95% CI 0.14, 0.26; pâ =â 1.02â à â 10â 10). This translated into an approximately 3.3 kg/m2 increase in BMI and an approximately 9.6 kg gain in body weight between TT and AA/CC homozygotes. The association between FTO genotypes and BMI was stronger in the cohorts with PCOS than in the general female populations from large genome-wide association studies. Deviation from an additive genetic model was observed in heavier populations.en_US
dc.description.abstractConclusions/interpretation: The effect of FTO SNPs on obesity-related traits in PCOS seems to be more than two times greater than the effect found in large population-based studies. This suggests an interaction between FTO and the metabolic context or polygenic background of PCOS.en_US
dc.description.abstractKeywords: BMIen_US
dc.rights© The Author(s) 2012en_US
dc.titleImpact of FTO genotypes on BMI and weight in polycystic ovary syndrome: a systematic review and meta-analysisen_US
dc.typeArticleen_US
dc.identifier.pmcidPMC3433670en_US
dc.contributor.corporatenameDepartment of Obstetrics and Gynecology-

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