Hdl Handle:
http://hdl.handle.net/10675.2/771
Title:
Lactate Produced by Glycogenolysis in Astrocytes Regulates Memory Processing
Authors:
Newman, Lori A.; Korol, Donna L.; Gold, Paul E.
Abstract:
When administered either systemically or centrally, glucose is a potent enhancer of memory processes. Measures of glucose levels in extracellular fluid in the rat hippocampus during memory tests reveal that these levels are dynamic, decreasing in response to memory tasks and loads; exogenous glucose blocks these decreases and enhances memory. The present experiments test the hypothesis that glucose enhancement of memory is mediated by glycogen storage and then metabolism to lactate in astrocytes, which provide lactate to neurons as an energy substrate. Sensitive bioprobes were used to measure brain glucose and lactate levels in 1-sec samples. Extracellular glucose decreased and lactate increased while rats performed a spatial working memory task. Intrahippocampal infusions of lactate enhanced memory in this task. In addition, pharmacological inhibition of astrocytic glycogenolysis impaired memory and this impairment was reversed by administration of lactate or glucose, both of which can provide lactate to neurons in the absence of glycogenolysis. Pharmacological block of the monocarboxylate transporter responsible for lactate uptake into neurons also impaired memory and this impairment was not reversed by either glucose or lactate. These findings support the view that astrocytes regulate memory formation by controlling the provision of lactate to support neuronal functions.
Editors:
Brann, Darrell W
Citation:
PLoS One. 2011 Dec 13; 6(12):e28427
Issue Date:
13-Dec-2011
URI:
http://hdl.handle.net/10675.2/771
DOI:
10.1371/journal.pone.0028427
PubMed ID:
22180782
PubMed Central ID:
PMC3236748
Type:
Article
ISSN:
1932-6203
Appears in Collections:
Department of Neurology: Faculty Research and Presentations

Full metadata record

DC FieldValue Language
dc.contributor.authorNewman, Lori A.en_US
dc.contributor.authorKorol, Donna L.en_US
dc.contributor.authorGold, Paul E.en_US
dc.contributor.editorBrann, Darrell W-
dc.date.accessioned2012-10-26T20:30:42Z-
dc.date.available2012-10-26T20:30:42Z-
dc.date.issued2011-12-13en_US
dc.identifier.citationPLoS One. 2011 Dec 13; 6(12):e28427en_US
dc.identifier.issn1932-6203en_US
dc.identifier.pmid22180782en_US
dc.identifier.doi10.1371/journal.pone.0028427en_US
dc.identifier.urihttp://hdl.handle.net/10675.2/771-
dc.description.abstractWhen administered either systemically or centrally, glucose is a potent enhancer of memory processes. Measures of glucose levels in extracellular fluid in the rat hippocampus during memory tests reveal that these levels are dynamic, decreasing in response to memory tasks and loads; exogenous glucose blocks these decreases and enhances memory. The present experiments test the hypothesis that glucose enhancement of memory is mediated by glycogen storage and then metabolism to lactate in astrocytes, which provide lactate to neurons as an energy substrate. Sensitive bioprobes were used to measure brain glucose and lactate levels in 1-sec samples. Extracellular glucose decreased and lactate increased while rats performed a spatial working memory task. Intrahippocampal infusions of lactate enhanced memory in this task. In addition, pharmacological inhibition of astrocytic glycogenolysis impaired memory and this impairment was reversed by administration of lactate or glucose, both of which can provide lactate to neurons in the absence of glycogenolysis. Pharmacological block of the monocarboxylate transporter responsible for lactate uptake into neurons also impaired memory and this impairment was not reversed by either glucose or lactate. These findings support the view that astrocytes regulate memory formation by controlling the provision of lactate to support neuronal functions.en_US
dc.rightsNewman et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.subjectResearch Articleen_US
dc.subjectBiologyen_US
dc.subjectAnatomy and Physiologyen_US
dc.subjectPhysiological Processesen_US
dc.subjectEnergy Metabolismen_US
dc.subjectNeuroscienceen_US
dc.subjectBehavioral Neuroscienceen_US
dc.subjectLearning and Memoryen_US
dc.subjectMedicineen_US
dc.subjectAnatomy and Physiologyen_US
dc.subjectPhysiological Processesen_US
dc.subjectEnergy Metabolismen_US
dc.subjectMetabolic Disordersen_US
dc.subjectGlycogen Storage Diseasesen_US
dc.subjectNeurologyen_US
dc.subjectDementiaen_US
dc.subjectAlzheimer Diseaseen_US
dc.subjectVascular Dementiaen_US
dc.subjectNeurodegenerative Diseasesen_US
dc.titleLactate Produced by Glycogenolysis in Astrocytes Regulates Memory Processingen_US
dc.typeArticleen_US
dc.identifier.pmcidPMC3236748en_US
dc.contributor.corporatenameDepartment of Neurology-
dc.contributor.corporatenameCollege of Graduate Studies-

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