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Reduced Serum Vitamin Dâ Binding Protein Levels Are Associated With Type 1 Diabetes
- Hdl Handle:
- http://hdl.handle.net/10675.2/758
- Title:
- Reduced Serum Vitamin Dâ Binding Protein Levels Are Associated With Type 1 Diabetes
- Authors:
- Abstract:
- null; OBJECTIVE: Previous studies have noted a specific association between type 1 diabetes and insufficient levels of vitamin D, as well as polymorphisms within genes related to vitamin D pathways. Here, we examined whether serum levels or genotypes of the vitamin Dâ binding protein (VDBP), a molecule key to the biologic actions of vitamin D, specifically associate with the disorder.; RESEARCH DESIGN AND METHODS: A retrospective, cross-sectional analysis of VDBP levels used samples from 472 individuals of similar age and sex distribution, including 153 control subjects, 203 patients with type 1 diabetes, and 116 first-degree relatives of type 1 diabetic patients. Single nucleotide polymorphism (SNP) typing for VDBP polymorphisms (SNP rs4588 and rs7041) was performed on this cohort to determine potential genetic correlations. In addition, SNP analysis of a second sample set of banked DNA samples from 1,502 type 1 diabetic patients and 1,880 control subjects also was used to determine genotype frequencies.; RESULTS: Serum VDBP levels were highest in healthy control subjects (median 423.5 µg/mL [range 193.5â 4,345.0; interquartile range 354.1â ]586), intermediate in first-degree relatives (402.9 µg/mL [204.7â 4,850.0; 329.6â 492.4]), and lowest in type 1 diabetic patients (385.3 µg/mL [99.3â 1,305.0; 328.3â 473.0]; P = 0.003 vs. control subjects). VDBP levels did not associate with serum vitamin D levels, age, or disease duration. However, VDBP levels were, overall, lower in male subjects (374.7 µg/mL [188.9â 1,602.0; 326.9â 449.9]) than female subjects (433.4 µg/mL [99.3â 4,850.0; 359.4â 567.8]; P < 0.0001). It is noteworthy that no differences in genotype frequencies of the VDBP polymorphisms were associated with serum VDBP levels or between type 1 diabetic patients and control subjects.; CONCLUSIONS: Serum VDBP levels are decreased in those with type 1 diabetes. These studies suggest that multiple components in the metabolic pathway of vitamin D may be altered in type 1 diabetes and, collectively, have the potential to influence disease pathogenesis.
- Citation:
- Diabetes. 2011 Oct 16; 60(10):2566-2570
- Issue Date:
- 16-Oct-2011
- URI:
- http://hdl.handle.net/10675.2/758
- DOI:
- 10.2337/db11-0576
- PubMed ID:
- 21844098
- PubMed Central ID:
- PMC3178281
- Type:
- Article
- ISSN:
- 1939-327X
- Appears in Collections:
- Center for Biotechnology and Genomic Medicine: Faculty Research and Presentations
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Blanton, Dustin | en_US |
dc.contributor.author | Han, Zhao | en_US |
dc.contributor.author | Bierschenk, Lindsey | en_US |
dc.contributor.author | Linga-Reddy, M.V. Prasad | en_US |
dc.contributor.author | Wang, Hongjie | en_US |
dc.contributor.author | Clare-Salzler, Michael | en_US |
dc.contributor.author | Haller, Michael | en_US |
dc.contributor.author | Schatz, Desmond | en_US |
dc.contributor.author | Myhr, Courtney | en_US |
dc.contributor.author | She, Jin-Xiong | en_US |
dc.contributor.author | Wasserfall, Clive | en_US |
dc.contributor.author | Atkinson, Mark | en_US |
dc.date.accessioned | 2012-10-26T20:30:39Z | - |
dc.date.available | 2012-10-26T20:30:39Z | - |
dc.date.issued | 2011-10-16 | en_US |
dc.identifier.citation | Diabetes. 2011 Oct 16; 60(10):2566-2570 | en_US |
dc.identifier.issn | 1939-327X | en_US |
dc.identifier.pmid | 21844098 | en_US |
dc.identifier.doi | 10.2337/db11-0576 | en_US |
dc.identifier.uri | http://hdl.handle.net/10675.2/758 | - |
dc.description.abstract | null | en_US |
dc.description.abstract | OBJECTIVE: Previous studies have noted a specific association between type 1 diabetes and insufficient levels of vitamin D, as well as polymorphisms within genes related to vitamin D pathways. Here, we examined whether serum levels or genotypes of the vitamin Dâ binding protein (VDBP), a molecule key to the biologic actions of vitamin D, specifically associate with the disorder. | en_US |
dc.description.abstract | RESEARCH DESIGN AND METHODS: A retrospective, cross-sectional analysis of VDBP levels used samples from 472 individuals of similar age and sex distribution, including 153 control subjects, 203 patients with type 1 diabetes, and 116 first-degree relatives of type 1 diabetic patients. Single nucleotide polymorphism (SNP) typing for VDBP polymorphisms (SNP rs4588 and rs7041) was performed on this cohort to determine potential genetic correlations. In addition, SNP analysis of a second sample set of banked DNA samples from 1,502 type 1 diabetic patients and 1,880 control subjects also was used to determine genotype frequencies. | en_US |
dc.description.abstract | RESULTS: Serum VDBP levels were highest in healthy control subjects (median 423.5 µg/mL [range 193.5â 4,345.0; interquartile range 354.1â ]586), intermediate in first-degree relatives (402.9 µg/mL [204.7â 4,850.0; 329.6â 492.4]), and lowest in type 1 diabetic patients (385.3 µg/mL [99.3â 1,305.0; 328.3â 473.0]; P = 0.003 vs. control subjects). VDBP levels did not associate with serum vitamin D levels, age, or disease duration. However, VDBP levels were, overall, lower in male subjects (374.7 µg/mL [188.9â 1,602.0; 326.9â 449.9]) than female subjects (433.4 µg/mL [99.3â 4,850.0; 359.4â 567.8]; P < 0.0001). It is noteworthy that no differences in genotype frequencies of the VDBP polymorphisms were associated with serum VDBP levels or between type 1 diabetic patients and control subjects. | en_US |
dc.description.abstract | CONCLUSIONS: Serum VDBP levels are decreased in those with type 1 diabetes. These studies suggest that multiple components in the metabolic pathway of vitamin D may be altered in type 1 diabetes and, collectively, have the potential to influence disease pathogenesis. | en_US |
dc.rights | © 2011 by the American Diabetes Association. | en_US |
dc.subject | Immunology and Transplantation | en_US |
dc.title | Reduced Serum Vitamin Dâ Binding Protein Levels Are Associated With Type 1 Diabetes | en_US |
dc.type | Article | en_US |
dc.identifier.pmcid | PMC3178281 | en_US |
dc.contributor.corporatename | Center for Biotechnology and Genomic Medicine | - |
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