Hdl Handle:
http://hdl.handle.net/10675.2/758
Title:
Reduced Serum Vitamin Dâ Binding Protein Levels Are Associated With Type 1 Diabetes
Authors:
Blanton, Dustin; Han, Zhao; Bierschenk, Lindsey; Linga-Reddy, M.V. Prasad; Wang, Hongjie; Clare-Salzler, Michael; Haller, Michael; Schatz, Desmond; Myhr, Courtney; She, Jin-Xiong; Wasserfall, Clive; Atkinson, Mark ( 0000-0001-8489-4782 )
Abstract:
null; OBJECTIVE: Previous studies have noted a specific association between type 1 diabetes and insufficient levels of vitamin D, as well as polymorphisms within genes related to vitamin D pathways. Here, we examined whether serum levels or genotypes of the vitamin Dâ binding protein (VDBP), a molecule key to the biologic actions of vitamin D, specifically associate with the disorder.; RESEARCH DESIGN AND METHODS: A retrospective, cross-sectional analysis of VDBP levels used samples from 472 individuals of similar age and sex distribution, including 153 control subjects, 203 patients with type 1 diabetes, and 116 first-degree relatives of type 1 diabetic patients. Single nucleotide polymorphism (SNP) typing for VDBP polymorphisms (SNP rs4588 and rs7041) was performed on this cohort to determine potential genetic correlations. In addition, SNP analysis of a second sample set of banked DNA samples from 1,502 type 1 diabetic patients and 1,880 control subjects also was used to determine genotype frequencies.; RESULTS: Serum VDBP levels were highest in healthy control subjects (median 423.5 µg/mL [range 193.5â 4,345.0; interquartile range 354.1â ]586), intermediate in first-degree relatives (402.9 µg/mL [204.7â 4,850.0; 329.6â 492.4]), and lowest in type 1 diabetic patients (385.3 µg/mL [99.3â 1,305.0; 328.3â 473.0]; P = 0.003 vs. control subjects). VDBP levels did not associate with serum vitamin D levels, age, or disease duration. However, VDBP levels were, overall, lower in male subjects (374.7 µg/mL [188.9â 1,602.0; 326.9â 449.9]) than female subjects (433.4 µg/mL [99.3â 4,850.0; 359.4â 567.8]; P < 0.0001). It is noteworthy that no differences in genotype frequencies of the VDBP polymorphisms were associated with serum VDBP levels or between type 1 diabetic patients and control subjects.; CONCLUSIONS: Serum VDBP levels are decreased in those with type 1 diabetes. These studies suggest that multiple components in the metabolic pathway of vitamin D may be altered in type 1 diabetes and, collectively, have the potential to influence disease pathogenesis.
Citation:
Diabetes. 2011 Oct 16; 60(10):2566-2570
Issue Date:
16-Oct-2011
URI:
http://hdl.handle.net/10675.2/758
DOI:
10.2337/db11-0576
PubMed ID:
21844098
PubMed Central ID:
PMC3178281
Type:
Article
ISSN:
1939-327X
Appears in Collections:
Center for Biotechnology and Genomic Medicine: Faculty Research and Presentations

Full metadata record

DC FieldValue Language
dc.contributor.authorBlanton, Dustinen_US
dc.contributor.authorHan, Zhaoen_US
dc.contributor.authorBierschenk, Lindseyen_US
dc.contributor.authorLinga-Reddy, M.V. Prasaden_US
dc.contributor.authorWang, Hongjieen_US
dc.contributor.authorClare-Salzler, Michaelen_US
dc.contributor.authorHaller, Michaelen_US
dc.contributor.authorSchatz, Desmonden_US
dc.contributor.authorMyhr, Courtneyen_US
dc.contributor.authorShe, Jin-Xiongen_US
dc.contributor.authorWasserfall, Cliveen_US
dc.contributor.authorAtkinson, Marken_US
dc.date.accessioned2012-10-26T20:30:39Z-
dc.date.available2012-10-26T20:30:39Z-
dc.date.issued2011-10-16en_US
dc.identifier.citationDiabetes. 2011 Oct 16; 60(10):2566-2570en_US
dc.identifier.issn1939-327Xen_US
dc.identifier.pmid21844098en_US
dc.identifier.doi10.2337/db11-0576en_US
dc.identifier.urihttp://hdl.handle.net/10675.2/758-
dc.description.abstractnullen_US
dc.description.abstractOBJECTIVE: Previous studies have noted a specific association between type 1 diabetes and insufficient levels of vitamin D, as well as polymorphisms within genes related to vitamin D pathways. Here, we examined whether serum levels or genotypes of the vitamin Dâ binding protein (VDBP), a molecule key to the biologic actions of vitamin D, specifically associate with the disorder.en_US
dc.description.abstractRESEARCH DESIGN AND METHODS: A retrospective, cross-sectional analysis of VDBP levels used samples from 472 individuals of similar age and sex distribution, including 153 control subjects, 203 patients with type 1 diabetes, and 116 first-degree relatives of type 1 diabetic patients. Single nucleotide polymorphism (SNP) typing for VDBP polymorphisms (SNP rs4588 and rs7041) was performed on this cohort to determine potential genetic correlations. In addition, SNP analysis of a second sample set of banked DNA samples from 1,502 type 1 diabetic patients and 1,880 control subjects also was used to determine genotype frequencies.en_US
dc.description.abstractRESULTS: Serum VDBP levels were highest in healthy control subjects (median 423.5 µg/mL [range 193.5â 4,345.0; interquartile range 354.1â ]586), intermediate in first-degree relatives (402.9 µg/mL [204.7â 4,850.0; 329.6â 492.4]), and lowest in type 1 diabetic patients (385.3 µg/mL [99.3â 1,305.0; 328.3â 473.0]; P = 0.003 vs. control subjects). VDBP levels did not associate with serum vitamin D levels, age, or disease duration. However, VDBP levels were, overall, lower in male subjects (374.7 µg/mL [188.9â 1,602.0; 326.9â 449.9]) than female subjects (433.4 µg/mL [99.3â 4,850.0; 359.4â 567.8]; P < 0.0001). It is noteworthy that no differences in genotype frequencies of the VDBP polymorphisms were associated with serum VDBP levels or between type 1 diabetic patients and control subjects.en_US
dc.description.abstractCONCLUSIONS: Serum VDBP levels are decreased in those with type 1 diabetes. These studies suggest that multiple components in the metabolic pathway of vitamin D may be altered in type 1 diabetes and, collectively, have the potential to influence disease pathogenesis.en_US
dc.rights© 2011 by the American Diabetes Association.en_US
dc.subjectImmunology and Transplantationen_US
dc.titleReduced Serum Vitamin Dâ Binding Protein Levels Are Associated With Type 1 Diabetesen_US
dc.typeArticleen_US
dc.identifier.pmcidPMC3178281en_US
dc.contributor.corporatenameCenter for Biotechnology and Genomic Medicine-

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