Vascular Protection by Angiotensin Receptor Antagonism Involves Differential VEGF Expression in Both Hemispheres after Experimental Stroke

Hdl Handle:
http://hdl.handle.net/10675.2/756
Title:
Vascular Protection by Angiotensin Receptor Antagonism Involves Differential VEGF Expression in Both Hemispheres after Experimental Stroke
Authors:
Guan, Weihua; Somanath, Payaningal R.; Kozak, Anna; Goc, Anna; El-Remessy, Azza B. ( 0000-0003-4386-1989 ) ; Ergul, Adviye; Johnson, Maribeth H.; Alhusban, Ahmed ( 0000-0003-1105-0620 ) ; Soliman, Sahar; Fagan, Susan C.
Abstract:
We identified that the angiotensin receptor antagonist, candesartan, has profound neurovascular protective properties when administered after ischemic stroke and was associated with a proangiogenic state at least partly explained by vascular endothelial growth factor A (VEGFA). However, the spatial distribution of vascular endothelial growth factor (VEGF) isoforms and their receptors remained unknown. Protein analysis identified a significant increase in vascular endothelial grow factor B (VEGFB) in the cerebrospinal fluid (CSF) and the ischemic hemispheres (with increased VEGF receptor 1 activation) of treated animals (p<0.05) which was co-occurring with an increase in protein kinase B (Akt) phosphorylation (p<0.05). An increase in VEGFA protein in the contralesional hemisphere corresponded to a significant increase in vascular density at seven days (p<0.01) after stroke onset
Citation:
PLoS One. 2011 Sep 1; 6(9):e24551
Issue Date:
1-Sep-2011
URI:
http://hdl.handle.net/10675.2/756
DOI:
10.1371/journal.pone.0024551
PubMed ID:
21912702
PubMed Central ID:
PMC3164729
Type:
Article
ISSN:
1932-6203
Appears in Collections:
Department of Physiology: Faculty Research and Presentations

Full metadata record

DC FieldValue Language
dc.contributor.authorGuan, Weihuaen_US
dc.contributor.authorSomanath, Payaningal R.en_US
dc.contributor.authorKozak, Annaen_US
dc.contributor.authorGoc, Annaen_US
dc.contributor.authorEl-Remessy, Azza B.en_US
dc.contributor.authorErgul, Adviyeen_US
dc.contributor.authorJohnson, Maribeth H.en_US
dc.contributor.authorAlhusban, Ahmeden_US
dc.contributor.authorSoliman, Saharen_US
dc.contributor.authorFagan, Susan C.en_US
dc.date.accessioned2012-10-26T20:28:40Z-
dc.date.available2012-10-26T20:28:40Z-
dc.date.issued2011-09-1en_US
dc.identifier.citationPLoS One. 2011 Sep 1; 6(9):e24551en_US
dc.identifier.issn1932-6203en_US
dc.identifier.pmid21912702en_US
dc.identifier.doi10.1371/journal.pone.0024551en_US
dc.identifier.urihttp://hdl.handle.net/10675.2/756-
dc.description.abstractWe identified that the angiotensin receptor antagonist, candesartan, has profound neurovascular protective properties when administered after ischemic stroke and was associated with a proangiogenic state at least partly explained by vascular endothelial growth factor A (VEGFA). However, the spatial distribution of vascular endothelial growth factor (VEGF) isoforms and their receptors remained unknown. Protein analysis identified a significant increase in vascular endothelial grow factor B (VEGFB) in the cerebrospinal fluid (CSF) and the ischemic hemispheres (with increased VEGF receptor 1 activation) of treated animals (p<0.05) which was co-occurring with an increase in protein kinase B (Akt) phosphorylation (p<0.05). An increase in VEGFA protein in the contralesional hemisphere corresponded to a significant increase in vascular density at seven days (p<0.01) after stroke onseten_US
dc.rightsGuan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.subjectResearch Articleen_US
dc.subjectBiologyen_US
dc.subjectDevelopmental Biologyen_US
dc.subjectMolecular Developmenten_US
dc.subjectSignalingen_US
dc.subjectMolecular Cell Biologyen_US
dc.subjectSignal Transductionen_US
dc.subjectSignaling Cascadesen_US
dc.subjectAkt Signaling Cascadeen_US
dc.subjectMedicineen_US
dc.subjectCardiovascularen_US
dc.subjectVascular Biologyen_US
dc.subjectNeurologyen_US
dc.subjectCerebrovascular Diseasesen_US
dc.subjectIschemic Strokeen_US
dc.subjectHemorrhagic Strokeen_US
dc.titleVascular Protection by Angiotensin Receptor Antagonism Involves Differential VEGF Expression in Both Hemispheres after Experimental Strokeen_US
dc.typeArticleen_US
dc.identifier.pmcidPMC3164729en_US
dc.contributor.corporatenameDepartment of Physiology-
dc.contributor.corporatenameDepartment of Neurology-
dc.contributor.corporatenameDepartment of Biostatistics and Epidemiology-
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