Cortical gene transcription response patterns to water maze training in aged mice

Hdl Handle:
http://hdl.handle.net/10675.2/752
Title:
Cortical gene transcription response patterns to water maze training in aged mice
Authors:
Park, Sung-Soo; Stranahan, Alexis M.; Chadwick, Wayne; Zhou, Yu; Wang, Liyun; Martin, Bronwen; Becker, Kevin G. ( 0000-0002-6794-6656 ) ; Maudsley, Stuart
Abstract:
Background: The hippocampus mediates the acquisition of spatial memory, but the memory trace is eventually transferred to the cortex. We have investigated transcriptional activation of pathways related to cognitive function in the cortex of the aged mouse by analyzing gene expression following water maze training.; Results: We identified genes that were differentially responsive in aged mice with accurate spatial performance during probe trials or repeated swimming sessions, relative to home cage conditions. Effective learners exhibited significantly greater activation of several pathways, such as the mitogen-activated protein kinase and insulin receptor signaling pathways, relative to swimmers. The genes encoding activity-related cytoskeletal protein (Arc) and brain-derived neurotrophic factor (BDNF) were upregulated in proficient learners, relative to swimmers and home cage controls, while the gene encoding Rho GTPase activating protein 32 (GRIT) was downregulated. We explored the regulation of Arc, BDNF, and GRIT expression in greater morphological detail using in situ hybridization. Recall during probe trials enhanced Arc expression across multiple cortical regions involved in the cognitive component of water maze learning, while BDNF expression was more homogeneously upregulated across cortical regions involved in the associational and sensorimotor aspects of water maze training. In contrast, levels of GRIT expression were uniformly reduced across all cortical regions examined.; Conclusions: These results suggest that cortical gene transcription is responsive to learning in aged mice that exhibit behavioral proficiency, and support a distributed hypothesis of memory storage across multiple cortical compartments.
Citation:
BMC Neurosci. 2011 Jun 29; 12:63
Issue Date:
29-Jun-2011
URI:
http://hdl.handle.net/10675.2/752
DOI:
10.1186/1471-2202-12-63
PubMed ID:
21714909
PubMed Central ID:
PMC3142531
Type:
Article
ISSN:
1471-2202
Appears in Collections:
Department of Physiology: Faculty Research and Presentations

Full metadata record

DC FieldValue Language
dc.contributor.authorPark, Sung-Sooen_US
dc.contributor.authorStranahan, Alexis M.en_US
dc.contributor.authorChadwick, Wayneen_US
dc.contributor.authorZhou, Yuen_US
dc.contributor.authorWang, Liyunen_US
dc.contributor.authorMartin, Bronwenen_US
dc.contributor.authorBecker, Kevin G.en_US
dc.contributor.authorMaudsley, Stuarten_US
dc.date.accessioned2012-10-26T20:27:56Z-
dc.date.available2012-10-26T20:27:56Z-
dc.date.issued2011-06-29en_US
dc.identifier.citationBMC Neurosci. 2011 Jun 29; 12:63en_US
dc.identifier.issn1471-2202en_US
dc.identifier.pmid21714909en_US
dc.identifier.doi10.1186/1471-2202-12-63en_US
dc.identifier.urihttp://hdl.handle.net/10675.2/752-
dc.description.abstractBackground: The hippocampus mediates the acquisition of spatial memory, but the memory trace is eventually transferred to the cortex. We have investigated transcriptional activation of pathways related to cognitive function in the cortex of the aged mouse by analyzing gene expression following water maze training.en_US
dc.description.abstractResults: We identified genes that were differentially responsive in aged mice with accurate spatial performance during probe trials or repeated swimming sessions, relative to home cage conditions. Effective learners exhibited significantly greater activation of several pathways, such as the mitogen-activated protein kinase and insulin receptor signaling pathways, relative to swimmers. The genes encoding activity-related cytoskeletal protein (Arc) and brain-derived neurotrophic factor (BDNF) were upregulated in proficient learners, relative to swimmers and home cage controls, while the gene encoding Rho GTPase activating protein 32 (GRIT) was downregulated. We explored the regulation of Arc, BDNF, and GRIT expression in greater morphological detail using in situ hybridization. Recall during probe trials enhanced Arc expression across multiple cortical regions involved in the cognitive component of water maze learning, while BDNF expression was more homogeneously upregulated across cortical regions involved in the associational and sensorimotor aspects of water maze training. In contrast, levels of GRIT expression were uniformly reduced across all cortical regions examined.en_US
dc.description.abstractConclusions: These results suggest that cortical gene transcription is responsive to learning in aged mice that exhibit behavioral proficiency, and support a distributed hypothesis of memory storage across multiple cortical compartments.en_US
dc.rightsCopyright ©2011 Park et al; licensee BioMed Central Ltd.en_US
dc.subjectResearch Articleen_US
dc.titleCortical gene transcription response patterns to water maze training in aged miceen_US
dc.typeArticleen_US
dc.identifier.pmcidPMC3142531en_US
dc.contributor.corporatenameDepartment of Physiology-

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