Ceramide in Stem Cell Differentiation and Embryo Development: Novel Functions of a Topological Cell-Signaling Lipid and the Concept of Ceramide Compartments

Hdl Handle:
http://hdl.handle.net/10675.2/645
Title:
Ceramide in Stem Cell Differentiation and Embryo Development: Novel Functions of a Topological Cell-Signaling Lipid and the Concept of Ceramide Compartments
Authors:
Bieberich, Erhard
Abstract:
In the last two decades, the view on the function of ceramide as a sole metabolic precursor for other sphingolipids has completely changed. A plethora of studies has shown that ceramide is an important lipid cell-signaling factor regulating apoptosis in a variety of cell types. With the advent of new stem cell technologies and knockout mice for specific steps in ceramide biosynthesis, this view is about to change again. Recent studies suggest that ceramide is a critical cell-signaling factor for stem cell differentiation and cell polarity, two processes at the core of embryo development. This paper discusses studies on ceramide using in vitro differentiated stem cells, embryo cultures, and knockout mice with the goal of linking specific developmental stages to exciting and novel functions of this lipid. Particular attention is devoted to the concept of ceramide as a topological cell-signaling lipid: a lipid that forms distinct structures (membrane domains and vesicles termed â sphingosomeâ ), which confines ceramide-induced cell signaling pathways to localized and even polarized compartments.
Citation:
J Lipids. 2011 Dec 29; 2011:610306
Issue Date:
29-Dec-2010
URI:
http://hdl.handle.net/10675.2/645
DOI:
10.1155/2011/610306
PubMed ID:
21490805
PubMed Central ID:
PMC3066852
Type:
Article
ISSN:
2090-3049
Appears in Collections:
Institute of Molecular Medicine and Genetics: Faculty Research and Presentations

Full metadata record

DC FieldValue Language
dc.contributor.authorBieberich, Erharden_US
dc.date.accessioned2012-10-26T16:26:58Z-
dc.date.available2012-10-26T16:26:58Z-
dc.date.issued2010-12-29en_US
dc.identifier.citationJ Lipids. 2011 Dec 29; 2011:610306en_US
dc.identifier.issn2090-3049en_US
dc.identifier.pmid21490805en_US
dc.identifier.doi10.1155/2011/610306en_US
dc.identifier.urihttp://hdl.handle.net/10675.2/645-
dc.description.abstractIn the last two decades, the view on the function of ceramide as a sole metabolic precursor for other sphingolipids has completely changed. A plethora of studies has shown that ceramide is an important lipid cell-signaling factor regulating apoptosis in a variety of cell types. With the advent of new stem cell technologies and knockout mice for specific steps in ceramide biosynthesis, this view is about to change again. Recent studies suggest that ceramide is a critical cell-signaling factor for stem cell differentiation and cell polarity, two processes at the core of embryo development. This paper discusses studies on ceramide using in vitro differentiated stem cells, embryo cultures, and knockout mice with the goal of linking specific developmental stages to exciting and novel functions of this lipid. Particular attention is devoted to the concept of ceramide as a topological cell-signaling lipid: a lipid that forms distinct structures (membrane domains and vesicles termed â sphingosomeâ ), which confines ceramide-induced cell signaling pathways to localized and even polarized compartments.en_US
dc.rightsCopyright © 2011 Erhard Bieberich.en_US
dc.subjectReview Articleen_US
dc.titleCeramide in Stem Cell Differentiation and Embryo Development: Novel Functions of a Topological Cell-Signaling Lipid and the Concept of Ceramide Compartmentsen_US
dc.typeArticleen_US
dc.identifier.pmcidPMC3066852en_US
dc.contributor.corporatenameInstitute of Molecular Medicine and Genetics-

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