Hdl Handle:
http://hdl.handle.net/10675.2/626
Title:
The role of RhoA/Rho kinase pathway in endothelial dysfunction
Authors:
Yao, Lin; Romero, Maritza J.; Toque, Haroldo A.; Yang, Guang; Caldwell, Ruth B. ( 0000-0003-0168-0354 ) ; Caldwell, Robert William
Abstract:
Endothelial dysfunction is a key event in the development of vascular disease, and it precedes clinically obvious vascular pathology. Abnormal activation of the RhoA/Rho kinase (ROCK) pathway has been found to elevate vascular tone through unbalancing the production of vasodilating and vasoconstricting substances. Inhibition of the RhoA/ROCK pathway can prevent endothelial dysfunction in a variety of pathological conditions. This review, based on recent molecular, cellular, and animal studies, focuses on the current understanding of the ROCK pathway and its roles in endothelial dysfunction.
Citation:
J Cardiovasc Dis Res. 2010 Oct-Dec; 1(4):165-170
Issue Date:
2010
URI:
http://hdl.handle.net/10675.2/626
DOI:
10.4103/0975-3583.74258
PubMed ID:
21264179
PubMed Central ID:
PMC3023892
Type:
Article
ISSN:
0976-2833
Appears in Collections:
Department of Pharmacology and Toxicology: Faculty Research and Presentations

Full metadata record

DC FieldValue Language
dc.contributor.authorYao, Linen_US
dc.contributor.authorRomero, Maritza J.en_US
dc.contributor.authorToque, Haroldo A.en_US
dc.contributor.authorYang, Guangen_US
dc.contributor.authorCaldwell, Ruth B.en_US
dc.contributor.authorCaldwell, Robert Williamen_US
dc.date.accessioned2012-10-26T16:26:55Z-
dc.date.available2012-10-26T16:26:55Z-
dc.date.issued2010en_US
dc.identifier.citationJ Cardiovasc Dis Res. 2010 Oct-Dec; 1(4):165-170en_US
dc.identifier.issn0976-2833en_US
dc.identifier.pmid21264179en_US
dc.identifier.doi10.4103/0975-3583.74258en_US
dc.identifier.urihttp://hdl.handle.net/10675.2/626-
dc.description.abstractEndothelial dysfunction is a key event in the development of vascular disease, and it precedes clinically obvious vascular pathology. Abnormal activation of the RhoA/Rho kinase (ROCK) pathway has been found to elevate vascular tone through unbalancing the production of vasodilating and vasoconstricting substances. Inhibition of the RhoA/ROCK pathway can prevent endothelial dysfunction in a variety of pathological conditions. This review, based on recent molecular, cellular, and animal studies, focuses on the current understanding of the ROCK pathway and its roles in endothelial dysfunction.en_US
dc.rights© Journal of Cardiovascular Disease Researchen_US
dc.subjectInvited Reviewen_US
dc.titleThe role of RhoA/Rho kinase pathway in endothelial dysfunctionen_US
dc.typeArticleen_US
dc.identifier.pmcidPMC3023892en_US
dc.contributor.corporatenameDepartment of Pharmacology and Toxicology-
dc.contributor.corporatenameVascular Biology Center-
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