Hdl Handle:
http://hdl.handle.net/10675.2/624
Title:
NOMA: A Preventable "Scourge" of African Children
Authors:
Ogbureke, Kalu U.E.; Ogbureke, Ezinne I
Abstract:
Noma is a serious orofacial gangrene originating intraorally in the gingival-oral mucosa complex before spreading extraorally to produce a visibly destructive ulcer. Although cases of noma are now rarely reported in the developed countries, it is still prevalent among children in third world countries, notably in sub-Sahara Africa, where poverty, ignorance, malnutrition, and preventable childhood infections are still common. This review summarizes historical, epidemiological, management, and research updates on noma with suggestions for its prevention and ultimate global eradication. The global annual incidence remains high at about 140,000 cases, with a mortality rate exceeding 90% for untreated diseases. Where the patients survive, noma defects result in unsightly facial disfigurement, intense scarring, trismus, oral incompetence, and social alienation. Although the etiology has long been held to be infectious, a definitive causal role between microorganisms cited, and noma has been difficult to establish. The management of noma with active disease requires antibiotics followed by reconstructive surgery. Current research efforts are focused towards a comprehensive understanding of the epidemiology, and further elucidation of the microbiology and pathogenesis of noma.; Keywords: Noma
Citation:
Open Dent J. 2010 Oct 21; 4:201-206
Issue Date:
21-Oct-2010
URI:
http://hdl.handle.net/10675.2/624
DOI:
10.2174/1874210601004010201
PubMed ID:
21243072
PubMed Central ID:
PMC3020568
Type:
Article
ISSN:
1874-2106
Appears in Collections:
Department of Oral Biology: Faculty Research and Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorOgbureke, Kalu U.E.en_US
dc.contributor.authorOgbureke, Ezinne Ien_US
dc.date.accessioned2012-10-26T16:26:54Z-
dc.date.available2012-10-26T16:26:54Z-
dc.date.issued2010-10-21en_US
dc.identifier.citationOpen Dent J. 2010 Oct 21; 4:201-206en_US
dc.identifier.issn1874-2106en_US
dc.identifier.pmid21243072en_US
dc.identifier.doi10.2174/1874210601004010201en_US
dc.identifier.urihttp://hdl.handle.net/10675.2/624-
dc.description.abstractNoma is a serious orofacial gangrene originating intraorally in the gingival-oral mucosa complex before spreading extraorally to produce a visibly destructive ulcer. Although cases of noma are now rarely reported in the developed countries, it is still prevalent among children in third world countries, notably in sub-Sahara Africa, where poverty, ignorance, malnutrition, and preventable childhood infections are still common. This review summarizes historical, epidemiological, management, and research updates on noma with suggestions for its prevention and ultimate global eradication. The global annual incidence remains high at about 140,000 cases, with a mortality rate exceeding 90% for untreated diseases. Where the patients survive, noma defects result in unsightly facial disfigurement, intense scarring, trismus, oral incompetence, and social alienation. Although the etiology has long been held to be infectious, a definitive causal role between microorganisms cited, and noma has been difficult to establish. The management of noma with active disease requires antibiotics followed by reconstructive surgery. Current research efforts are focused towards a comprehensive understanding of the epidemiology, and further elucidation of the microbiology and pathogenesis of noma.en_US
dc.description.abstractKeywords: Nomaen_US
dc.rights© Ogbureke and Ogbureke; Licensee Bentham Open.en_US
dc.titleNOMA: A Preventable "Scourge" of African Childrenen_US
dc.typeArticleen_US
dc.identifier.pmcidPMC3020568en_US
dc.contributor.corporatenameDepartment of Oral Biology-
dc.contributor.corporatenameDepartment of Oral Health and Diagnostic Sciences-

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