Hdl Handle:
http://hdl.handle.net/10675.2/621348
Title:
Structural, Kinetic and Functional Properties of CAP1/AC Complexes
Authors:
Mehrotra, Simran
Abstract:
The major cause of death in pancreatic cancer is due to metastases; therefore, it is important to study the mechanism by which the pancreatic cancer cells migrate and invade. This would help advance therapeutics and ultimately help prolong survival. Adenylyl cyclase-associated protein 1 (CAP1) is a scaffold protein that is involved in the regulation of actin microfilament formation, which ultimately leads to cell migration and invasion. CAP1 binds to G-actin inhibiting polymerization. We first tested whether CAP1 binds to adenylyl cyclase (AC) by performing co-immunoprecipitation. We found that CAP1 not only interacts with G-actin, but also with a number of AC isoforms: AC1, AC3, AC4 and AC7. Further studies need to be done to determine how CAP1/AC/G-actin interact and the impact of these interactions on the invasive behavior of pancreatic cancer cells.
Affiliation:
Department of Biological Sciences
Issue Date:
Mar-2017
URI:
http://hdl.handle.net/10675.2/621348
Type:
Other
Language:
en
Description:
Poster presented at the 18th Annual Phi Kappa Phi Student Research and Fine Arts Conference
Sponsors:
Augusta University Scholarly Activity Award
Appears in Collections:
Department of Biological Sciences: Student Research and Presentations; 18th Annual PKP Student Research and Fine Arts Conference: Posters

Full metadata record

DC FieldValue Language
dc.contributor.authorMehrotra, Simranen
dc.date.accessioned2017-03-14T12:22:58Z-
dc.date.available2017-03-14T12:22:58Z-
dc.date.issued2017-03-
dc.identifier.urihttp://hdl.handle.net/10675.2/621348-
dc.descriptionPoster presented at the 18th Annual Phi Kappa Phi Student Research and Fine Arts Conferenceen
dc.description.abstractThe major cause of death in pancreatic cancer is due to metastases; therefore, it is important to study the mechanism by which the pancreatic cancer cells migrate and invade. This would help advance therapeutics and ultimately help prolong survival. Adenylyl cyclase-associated protein 1 (CAP1) is a scaffold protein that is involved in the regulation of actin microfilament formation, which ultimately leads to cell migration and invasion. CAP1 binds to G-actin inhibiting polymerization. We first tested whether CAP1 binds to adenylyl cyclase (AC) by performing co-immunoprecipitation. We found that CAP1 not only interacts with G-actin, but also with a number of AC isoforms: AC1, AC3, AC4 and AC7. Further studies need to be done to determine how CAP1/AC/G-actin interact and the impact of these interactions on the invasive behavior of pancreatic cancer cells.en
dc.description.sponsorshipAugusta University Scholarly Activity Awarden
dc.language.isoenen
dc.subjectPancreatic Neoplasmsen
dc.subjectAdenylyl Cyclasesen
dc.subjectImmunoprecipitationen
dc.titleStructural, Kinetic and Functional Properties of CAP1/AC Complexesen
dc.typeOtheren
dc.contributor.departmentDepartment of Biological Sciencesen
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