Hdl Handle:
http://hdl.handle.net/10675.2/621304
Title:
Curcumin Conjugates as Potential Anti-inflammatory Agents
Authors:
Thomas, Sean J.; Panda, Siva S.
Abstract:
Curcumin, a component of turmeric (Curcuma longa), is a compound that is beginning to gain significant notoriety for its many medicinal uses. While curcumin has been used as a remedy to treat a wide variety of ailments for centuries, a considerable amount of research is currently being conducted to determine its anticancer, anti-inflammatory and antimicrobial capacity. Current anti-inflammatory medications and cancer treatments, although effective, can produce serious side effects, which in some cases can be irreversible. Although curcumin exhibit qualities that show promise for effectively treating certain life-threatening diseases, they do come with some drawbacks. This research is concerned with synthesizing potential curcumin based drug candidates that combat inflammation. By coupling curcumin with amino acids, we hoped to develop potent conjugates and diminished side effects. To do this, optimal reaction conditions had to be established, which involved utilizing different coupling reagents and solvents at varied temperatures. Once favorable conditions were obtained, several curcumin-amino acid conjugates were successfully synthesized in excellent yield without alterations to chirality. In doing so, an efficient methodology for synthesizing these conjugates was developed. The details of these compounds and anti-inflammatory property will be discussed in the conference.
Affiliation:
Department of Chemistry & Physics
Issue Date:
Mar-2017
URI:
http://hdl.handle.net/10675.2/621304
Type:
Presentation
Language:
en
Description:
Presentation given at the 18th Annual Phi Kappa Phi Student Research and Fine Arts Conference
Appears in Collections:
Department of Chemistry and Physics: Student Research and Presentations; 18th Annual PKP Student Research and Fine Arts Conference: Oral Symposia II

Full metadata record

DC FieldValue Language
dc.contributor.authorThomas, Sean J.en
dc.contributor.authorPanda, Siva S.en
dc.date.accessioned2017-03-06T19:11:40Z-
dc.date.available2017-03-06T19:11:40Z-
dc.date.issued2017-03-
dc.identifier.urihttp://hdl.handle.net/10675.2/621304-
dc.descriptionPresentation given at the 18th Annual Phi Kappa Phi Student Research and Fine Arts Conferenceen
dc.description.abstractCurcumin, a component of turmeric (Curcuma longa), is a compound that is beginning to gain significant notoriety for its many medicinal uses. While curcumin has been used as a remedy to treat a wide variety of ailments for centuries, a considerable amount of research is currently being conducted to determine its anticancer, anti-inflammatory and antimicrobial capacity. Current anti-inflammatory medications and cancer treatments, although effective, can produce serious side effects, which in some cases can be irreversible. Although curcumin exhibit qualities that show promise for effectively treating certain life-threatening diseases, they do come with some drawbacks. This research is concerned with synthesizing potential curcumin based drug candidates that combat inflammation. By coupling curcumin with amino acids, we hoped to develop potent conjugates and diminished side effects. To do this, optimal reaction conditions had to be established, which involved utilizing different coupling reagents and solvents at varied temperatures. Once favorable conditions were obtained, several curcumin-amino acid conjugates were successfully synthesized in excellent yield without alterations to chirality. In doing so, an efficient methodology for synthesizing these conjugates was developed. The details of these compounds and anti-inflammatory property will be discussed in the conference.en
dc.language.isoenen
dc.subjectAnti-Inflammatory Agentsen
dc.subjectCurcuminen
dc.subjectInflammationen
dc.titleCurcumin Conjugates as Potential Anti-inflammatory Agentsen
dc.typePresentationen
dc.contributor.departmentDepartment of Chemistry & Physicsen
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