Marker Co-Expression Analysis of Initial Cellular Events in the Critical-Size Rat Calvarial Defect Model and the Effect of Bone Morphogenetic Protein-2 (rhBMP-2)

Hdl Handle:
http://hdl.handle.net/10675.2/612264
Title:
Marker Co-Expression Analysis of Initial Cellular Events in the Critical-Size Rat Calvarial Defect Model and the Effect of Bone Morphogenetic Protein-2 (rhBMP-2)
Authors:
Capetillo, Joseph F.
Abstract:
Craniofacial defects can result from congenital malformations, trauma, tumor resection,periodontal disease, post-extraction ridge remodeling, and peri-implantitis. Regenerationof bone is critical to achieving functional and esthetic outcomes in the rehabilitation ofsuch defects. Traditional strategies for osseous regeneration include a multiple ofsurgical techniques utilizing autologous bone, cadaver-sourced allogeneic or xenogeneicbone, synthetic bone biomaterials, barrier membranes, or combinations thereof(Wikesjö, Qahash 2009). The need to enhance the predictability of regeneration inespecially large defects that cannot heal adequately without intervention (critical-sizedefects) has led to recent development of protein- and cell-based technologies.[Introduction, first paragraph]
Affiliation:
Department of Oral Biology
Issue Date:
15-Apr-2016
URI:
http://hdl.handle.net/10675.2/612264
Type:
Thesis
Language:
en
Appears in Collections:
Department of Oral Biology Theses and Dissertations; Theses and Dissertations

Full metadata record

DC FieldValue Language
dc.contributor.authorCapetillo, Joseph F.en
dc.date.accessioned2016-06-08T20:34:29Z-
dc.date.available2016-06-08T20:34:29Z-
dc.date.issued2016-04-15-
dc.identifier.urihttp://hdl.handle.net/10675.2/612264-
dc.description.abstractCraniofacial defects can result from congenital malformations, trauma, tumor resection,periodontal disease, post-extraction ridge remodeling, and peri-implantitis. Regenerationof bone is critical to achieving functional and esthetic outcomes in the rehabilitation ofsuch defects. Traditional strategies for osseous regeneration include a multiple ofsurgical techniques utilizing autologous bone, cadaver-sourced allogeneic or xenogeneicbone, synthetic bone biomaterials, barrier membranes, or combinations thereof(Wikesjö, Qahash 2009). The need to enhance the predictability of regeneration inespecially large defects that cannot heal adequately without intervention (critical-sizedefects) has led to recent development of protein- and cell-based technologies.[Introduction, first paragraph]en
dc.language.isoenen
dc.subjectBMP-2en
dc.subjectrhBMP-2en
dc.subjectbone biologyen
dc.subjectRunx2en
dc.titleMarker Co-Expression Analysis of Initial Cellular Events in the Critical-Size Rat Calvarial Defect Model and the Effect of Bone Morphogenetic Protein-2 (rhBMP-2)en
dc.typeThesisen
dc.contributor.departmentDepartment of Oral Biologyen
dc.contributor.committeememberColenman, Brandon Dickinson, Douglas Wikesjo, Ulfen
dc.description.advisorMesser, Reginaen
dc.description.degreeMaster of Science in Oral Biologyen
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