Balanced Dopamine Is Critical for Pattern Completion during Associative Memory Recall

Hdl Handle:
http://hdl.handle.net/10675.2/603
Title:
Balanced Dopamine Is Critical for Pattern Completion during Associative Memory Recall
Authors:
Li, Fei; Wang, Lei Phillip; Shen, Xiaoming; Tsien, Joe Z.
Abstract:
Pattern completion, the ability to retrieve complete memories initiated by partial cues, is a critical feature of the memory process. However, little is known regarding the molecular and cellular mechanisms underlying this process. To study the role of dopamine in memory recall, we have analyzed dopamine transporter heterozygous knockout mice (DAT+/-), and found that while these mice possess normal learning, consolidation, and memory recall under full cue conditions, they exhibit specific deficits in pattern completion under partial cue condition. This form of memory recall deficit in the dopamine transporter heterozygous knockout mice can be reversed by a low dose of the dopamine antagonist haloperidol, further confirming that the inability to retrieve memory patterns is a result of dopamine imbalance. Therefore, our results reveal that a delicate control of the brain's dopamine level is critical for pattern completion during associative memory recall.
Citation:
PLoS One. 2010 Oct 27; 5(10):e15401
Issue Date:
27-Oct-2010
URI:
http://hdl.handle.net/10675.2/603
DOI:
10.1371/journal.pone.0015401
PubMed ID:
21060884
PubMed Central ID:
PMC2965183
Type:
Article
ISSN:
1932-6203
Appears in Collections:
Brain & Behavior Discovery Institute: Faculty Research and Presentations

Full metadata record

DC FieldValue Language
dc.contributor.authorLi, Feien_US
dc.contributor.authorWang, Lei Phillipen_US
dc.contributor.authorShen, Xiaomingen_US
dc.contributor.authorTsien, Joe Z.en_US
dc.date.accessioned2012-10-26T16:26:51Z-
dc.date.available2012-10-26T16:26:51Z-
dc.date.issued2010-10-27en_US
dc.identifier.citationPLoS One. 2010 Oct 27; 5(10):e15401en_US
dc.identifier.issn1932-6203en_US
dc.identifier.pmid21060884en_US
dc.identifier.doi10.1371/journal.pone.0015401en_US
dc.identifier.urihttp://hdl.handle.net/10675.2/603-
dc.description.abstractPattern completion, the ability to retrieve complete memories initiated by partial cues, is a critical feature of the memory process. However, little is known regarding the molecular and cellular mechanisms underlying this process. To study the role of dopamine in memory recall, we have analyzed dopamine transporter heterozygous knockout mice (DAT+/-), and found that while these mice possess normal learning, consolidation, and memory recall under full cue conditions, they exhibit specific deficits in pattern completion under partial cue condition. This form of memory recall deficit in the dopamine transporter heterozygous knockout mice can be reversed by a low dose of the dopamine antagonist haloperidol, further confirming that the inability to retrieve memory patterns is a result of dopamine imbalance. Therefore, our results reveal that a delicate control of the brain's dopamine level is critical for pattern completion during associative memory recall.en_US
dc.rightsLi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.subjectResearch Articleen_US
dc.subjectBiologyen_US
dc.subjectBiochemistryen_US
dc.subjectNeurochemistryen_US
dc.subjectNeurochemicalsen_US
dc.subjectDopamineen_US
dc.subjectNerve Growth Factoren_US
dc.subjectSynaptic Plasticityen_US
dc.subjectBiotechnologyen_US
dc.subjectGenetic Engineeringen_US
dc.subjectTransgenicsen_US
dc.subjectModel Organismsen_US
dc.subjectAnimal Modelsen_US
dc.subjectMouseen_US
dc.subjectNeuroscienceen_US
dc.subjectCognitive Neuroscienceen_US
dc.subjectWorking Memoryen_US
dc.subjectAnimal Cognitionen_US
dc.subjectBehavioral Neuroscienceen_US
dc.subjectLearning and Memoryen_US
dc.subjectNeural Homeostasisen_US
dc.subjectNeurobiology of Disease and Regenerationen_US
dc.subjectMedicineen_US
dc.subjectDrugs and Devicesen_US
dc.subjectBehavioral Pharmacologyen_US
dc.subjectRecreational Drug Useen_US
dc.subjectNeuropharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDopamineen_US
dc.subject.meshDopamine Plasma Membrane Transport Proteinsen_US
dc.subject.meshMemoryen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Knockouten_US
dc.titleBalanced Dopamine Is Critical for Pattern Completion during Associative Memory Recallen_US
dc.typeArticleen_US
dc.identifier.pmcidPMC2965183en_US
dc.contributor.corporatenameBrain & Behavior Discovery Institute-

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