Hdl Handle:
http://hdl.handle.net/10675.2/601045
Title:
Investigating the Effects of DNA Damaging Agents on Survival in Hob1 Knockout Strains of Schizosaccharomyces Pombe
Authors:
Hashmi, Natasha
Abstract:
An important aspect of cancer research investigates why one tumor is resistant to chemotherapy while another tumor is sensitive to chemotherapy. The gene BIN1 when expressed renders chemoresistant cancer cells sensitive to DNA damaging agents in mammals. To better understand the extent of the chemosensitivity when BIN1 is expressed we are going to utilize the fission yeast, Schizosaccharomyces pombe. S. pombe has a functional homolog of BIN1 called HOB1 (Homolog Of Bin1). We have exposed both wild type and hob1Δ yeast strains to a wild variety of DNA damaging agents at various concentrations and accessed their survival rates. By comparing the sensitivities of wild type yeast to yeast lacking a function Hob1 protein we can have a better understanding of the role mammalian Bin1 protein plays in rendering cancer cells chemosensitive.
Affiliation:
Department of Biological Sciences
Issue Date:
Mar-2016
URI:
http://hdl.handle.net/10675.2/601045
Type:
Other
Language:
en_US
Description:
Poster presented at the 17th Annual Phi Kappa Phi Student Research and Fine Arts Conference
Appears in Collections:
17th Annual Phi Kappa Phi Student Research and Fine Arts Conference: Posters

Full metadata record

DC FieldValue Language
dc.contributor.authorHashmi, Natashaen
dc.date.accessioned2016-03-09T16:11:04Zen
dc.date.available2016-03-09T16:11:04Zen
dc.date.issued2016-03en
dc.identifier.urihttp://hdl.handle.net/10675.2/601045en
dc.descriptionPoster presented at the 17th Annual Phi Kappa Phi Student Research and Fine Arts Conferenceen
dc.description.abstractAn important aspect of cancer research investigates why one tumor is resistant to chemotherapy while another tumor is sensitive to chemotherapy. The gene BIN1 when expressed renders chemoresistant cancer cells sensitive to DNA damaging agents in mammals. To better understand the extent of the chemosensitivity when BIN1 is expressed we are going to utilize the fission yeast, Schizosaccharomyces pombe. S. pombe has a functional homolog of BIN1 called HOB1 (Homolog Of Bin1). We have exposed both wild type and hob1Δ yeast strains to a wild variety of DNA damaging agents at various concentrations and accessed their survival rates. By comparing the sensitivities of wild type yeast to yeast lacking a function Hob1 protein we can have a better understanding of the role mammalian Bin1 protein plays in rendering cancer cells chemosensitive.en
dc.language.isoen_USen
dc.subjectNeoplasmsen
dc.subjectYeast, Drieden
dc.subjectYeast, Drieden
dc.subjectAnimalsen
dc.subjectAnimalsen
dc.titleInvestigating the Effects of DNA Damaging Agents on Survival in Hob1 Knockout Strains of Schizosaccharomyces Pombeen_US
dc.typeOtheren
dc.contributor.departmentDepartment of Biological Sciencesen
dc.description.advisorAbdulovic-Cui, Amyen
All Items in Scholarly Commons are protected by copyright, with all rights reserved, unless otherwise indicated.