Hdl Handle:
http://hdl.handle.net/10675.2/601032
Title:
Enhancing Radiation Sensitivity in Anaplastic Thyroid Cancer: Novel Therapeutic Strategies to Target a Killer
Authors:
Latremouille, Rachel
Abstract:
Anaplastic thyroid carcinoma (ATC) is an aggressive cancer, with those diagnosed typically living only sixth months. This cancer normally effects the elderly, with an estimated 67% of patients being 70 years of age or older. One of the reasons ATC is such a deadly disease is the lack of effective treatment options. While chemotherapy and radiation are effective treatments for many cancers, they usually have little efficacy for ATC patients. However, our lab has discovered that cytokeratin-8 (CK8), a protein that plays a structural role in normal cells, has a novel and unanticipated role in promoting growth of ATC cells. Knock- down of CK8 in fast-growing ATC results in in a near-complete abrogation of cell growth, and an increase in apoptosis, in which the cell programs itself to die. Since ATC is normally resistant to radiation therapy, and one of the mechanisms of action for radiation in treating cancer is inducing DNA damage and subsequently apoptosis, we hypothesize there may be the potential for increased effectiveness between these two observations. To this end, we are investigating whether knocking down CK8 in ATC cell lines will increase radiation sensitivity, and will present the results at the conference.
Affiliation:
Department of Health Sciences
Issue Date:
Mar-2016
URI:
http://hdl.handle.net/10675.2/601032
Type:
Other
Language:
en_US
Description:
Poster presented at the 17th Annual Phi Kappa Phi Student Research and Fine Arts Conference
Appears in Collections:
17th Annual Phi Kappa Phi Student Research and Fine Arts Conference: Posters

Full metadata record

DC FieldValue Language
dc.contributor.authorLatremouille, Rachelen
dc.date.accessioned2016-03-09T16:28:28Zen
dc.date.available2016-03-09T16:28:28Zen
dc.date.issued2016-03en
dc.identifier.urihttp://hdl.handle.net/10675.2/601032en
dc.descriptionPoster presented at the 17th Annual Phi Kappa Phi Student Research and Fine Arts Conferenceen
dc.description.abstractAnaplastic thyroid carcinoma (ATC) is an aggressive cancer, with those diagnosed typically living only sixth months. This cancer normally effects the elderly, with an estimated 67% of patients being 70 years of age or older. One of the reasons ATC is such a deadly disease is the lack of effective treatment options. While chemotherapy and radiation are effective treatments for many cancers, they usually have little efficacy for ATC patients. However, our lab has discovered that cytokeratin-8 (CK8), a protein that plays a structural role in normal cells, has a novel and unanticipated role in promoting growth of ATC cells. Knock- down of CK8 in fast-growing ATC results in in a near-complete abrogation of cell growth, and an increase in apoptosis, in which the cell programs itself to die. Since ATC is normally resistant to radiation therapy, and one of the mechanisms of action for radiation in treating cancer is inducing DNA damage and subsequently apoptosis, we hypothesize there may be the potential for increased effectiveness between these two observations. To this end, we are investigating whether knocking down CK8 in ATC cell lines will increase radiation sensitivity, and will present the results at the conference.en
dc.language.isoen_USen
dc.subjectThyroid Carcinoma, Anaplasticen
dc.subjectApoptosisen
dc.subjectRadiation Toleranceen
dc.titleEnhancing Radiation Sensitivity in Anaplastic Thyroid Cancer: Novel Therapeutic Strategies to Target a Killeren_US
dc.typeOtheren
dc.contributor.departmentDepartment of Health Sciencesen
dc.description.advisorWeinberger, Paul; Mourad, Waleeden
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