Hdl Handle:
http://hdl.handle.net/10675.2/601029
Title:
Effects of Monoamine Uptake Inhibitors in an Assay of Pain Depressed Behavior in Male Mice
Authors:
Alexander, Khadijah; Rodriguez, Taylor; Sarfo, Amma
Abstract:
Consequences of pain include stimulation of some behaviors (e.g. reflexive withdrawal from stimuli), and depression of others (e.g. exercise, and work). Pain depressed behaviors are among the primary diagnostic and treatment concerns for physicians, but preclinical research has often explored pain stimulated behaviors. This discrepancy between basic research and clinical application may be one obstacle to the development of new pain treatments. In the present study, we modeled pain-related depression of behavior by observing nesting behavior in male ICR mice. Nest building is an innate mouse behavior that is reduced when the mouse is exposed to a pain stimulus. Pain-related depression of nesting is blocked by the clinically effective nonsteroidal anti-inflammatory drug (NSAID) ketoprofen. This project examines effects of monoamine uptake inhibitors with varying selectivity for serotonin (5HT), norepinephrine (NE) and dopamine (DA) on pain-related depression of nesting. Citalopram (5HT-selective), nisoxetine (NE-selective), milnacipran (mixed action, 5HT/NE-selective), and bupropion (DA-selective) were evaluated for their ability to block pain-related depression of nesting. Results show that the monoamine uptake inhibitors lacking significant dopamine had no effect on pain-depressed nesting. This finding is consistent with previous work suggesting that dopamine may be a key neurochemical target in the treatment of pain-related depression of behavior. Funding Source: Department of Psychological Sciences
Affiliation:
Department of Psychological Sciences
Issue Date:
Mar-2016
URI:
http://hdl.handle.net/10675.2/601029
Type:
Other
Language:
en_US
Description:
Poster presented at the 17th Annual Phi Kappa Phi Student Research and Fine Arts Conference
Appears in Collections:
17th Annual Phi Kappa Phi Student Research and Fine Arts Conference: Posters

Full metadata record

DC FieldValue Language
dc.contributor.authorAlexander, Khadijahen
dc.contributor.authorRodriguez, Tayloren
dc.contributor.authorSarfo, Ammaen
dc.date.accessioned2016-03-09T15:28:19Zen
dc.date.available2016-03-09T15:28:19Zen
dc.date.issued2016-03en
dc.identifier.urihttp://hdl.handle.net/10675.2/601029en
dc.descriptionPoster presented at the 17th Annual Phi Kappa Phi Student Research and Fine Arts Conferenceen
dc.description.abstractConsequences of pain include stimulation of some behaviors (e.g. reflexive withdrawal from stimuli), and depression of others (e.g. exercise, and work). Pain depressed behaviors are among the primary diagnostic and treatment concerns for physicians, but preclinical research has often explored pain stimulated behaviors. This discrepancy between basic research and clinical application may be one obstacle to the development of new pain treatments. In the present study, we modeled pain-related depression of behavior by observing nesting behavior in male ICR mice. Nest building is an innate mouse behavior that is reduced when the mouse is exposed to a pain stimulus. Pain-related depression of nesting is blocked by the clinically effective nonsteroidal anti-inflammatory drug (NSAID) ketoprofen. This project examines effects of monoamine uptake inhibitors with varying selectivity for serotonin (5HT), norepinephrine (NE) and dopamine (DA) on pain-related depression of nesting. Citalopram (5HT-selective), nisoxetine (NE-selective), milnacipran (mixed action, 5HT/NE-selective), and bupropion (DA-selective) were evaluated for their ability to block pain-related depression of nesting. Results show that the monoamine uptake inhibitors lacking significant dopamine had no effect on pain-depressed nesting. This finding is consistent with previous work suggesting that dopamine may be a key neurochemical target in the treatment of pain-related depression of behavior. Funding Source: Department of Psychological Sciencesen
dc.language.isoen_USen
dc.subjectMiceen
dc.subjectPainen
dc.subjectNesting Behavioren
dc.subjectDopamineen
dc.titleEffects of Monoamine Uptake Inhibitors in an Assay of Pain Depressed Behavior in Male Miceen_US
dc.typeOtheren
dc.contributor.departmentDepartment of Psychological Sciencesen
dc.description.advisorMiller, Lawrenceen
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