Bionanofabrication: engineering biomaterials for in situ remodeling and drug delivery

Hdl Handle:
http://hdl.handle.net/10675.2/600407
Title:
Bionanofabrication: engineering biomaterials for in situ remodeling and drug delivery
Authors:
Batt, Carl A.
Abstract:
The bionanofabrication of smart materials presents opportunities in fields as far ranging as food science and medicine. The tools of molecular biology allow for the in vivo and in vitro production of unique biomolecules enabling not only the direct(ed) creation of novel proteins but also catalysts that can then produce other non-protein polymers. An example is the biodegradable polymer, polyhydroxyalkanoate (PHA), which is normally produced by a number of different bacteria. It is synthesized through a series of three enzymes but only one, polyhydroxalkanoate synthetase (PHAC) is required for the conversion of a soluble CoA-substrate into an insoluble hydrophobic polymer. Our laboratory has pioneered the in situ formation of PHA by engineering PHAC and targeting it toward fabricated and native substrates. Once on-site polymer formation can be initiated by introducing the substrate. Alternatively polymers can be formed in vitro and then delivered to the target site. Beyond the localized impact by the introduction of significant quantities of a highly hydrophobic polymer, PHA can also be used as a vehicle for the delivery of therapeutic drugs and once there release their cargo through its normal degradation process. Applications to cancer therapy and in situ engineering of microvasculature will be presented.
Affiliation:
Cornell University
Issue Date:
26-Feb-2016
URI:
http://hdl.handle.net/10675.2/600407
Additional Links:
http://www.augusta.edu/colleges/scimath/chemistryandphysics/materials-thursday.php
Type:
Presentation
Language:
en
Description:
Presentation given at the Materials Science Research Seminar Series on Friday, February 26, 2016, 1 – 2 PM.
Series/Report no.:
Spring; 2016
Appears in Collections:
Materials Science Research Seminar Series

Full metadata record

DC FieldValue Language
dc.contributor.authorBatt, Carl A.en
dc.date.accessioned2016-02-29T18:44:08Zen
dc.date.available2016-02-29T18:44:08Zen
dc.date.issued2016-02-26en
dc.identifier.urihttp://hdl.handle.net/10675.2/600407en
dc.descriptionPresentation given at the Materials Science Research Seminar Series on Friday, February 26, 2016, 1 – 2 PM.en
dc.description.abstractThe bionanofabrication of smart materials presents opportunities in fields as far ranging as food science and medicine. The tools of molecular biology allow for the in vivo and in vitro production of unique biomolecules enabling not only the direct(ed) creation of novel proteins but also catalysts that can then produce other non-protein polymers. An example is the biodegradable polymer, polyhydroxyalkanoate (PHA), which is normally produced by a number of different bacteria. It is synthesized through a series of three enzymes but only one, polyhydroxalkanoate synthetase (PHAC) is required for the conversion of a soluble CoA-substrate into an insoluble hydrophobic polymer. Our laboratory has pioneered the in situ formation of PHA by engineering PHAC and targeting it toward fabricated and native substrates. Once on-site polymer formation can be initiated by introducing the substrate. Alternatively polymers can be formed in vitro and then delivered to the target site. Beyond the localized impact by the introduction of significant quantities of a highly hydrophobic polymer, PHA can also be used as a vehicle for the delivery of therapeutic drugs and once there release their cargo through its normal degradation process. Applications to cancer therapy and in situ engineering of microvasculature will be presented.en
dc.language.isoenen
dc.relation.ispartofseriesSpringen
dc.relation.ispartofseries2016en
dc.relation.urlhttp://www.augusta.edu/colleges/scimath/chemistryandphysics/materials-thursday.phpen
dc.subjectBionanofabricationen
dc.subjectMolecular Biologyen
dc.subjectPolyhydroxalkanoate Synthetaseen
dc.subjectCanceren
dc.titleBionanofabrication: engineering biomaterials for in situ remodeling and drug deliveryen
dc.typePresentationen
dc.contributor.departmentCornell Universityen
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