Pulmonary Stress in the Alcoholic and Obese Lung

Hdl Handle:
http://hdl.handle.net/10675.2/579467
Title:
Pulmonary Stress in the Alcoholic and Obese Lung
Authors:
Thomas, Amanda Blair
Abstract:
In the United States today, alcoholism and obesity are increasingly becoming issues for a vast age group from young children to geriatric adults. Alcoholism and obesity have been extensively studied as separate entities that have been proven to change metabolism and cause over-lapping health issues, which prompted us to study them in conjunction with one another, especially in the lungs. One major link between these two alarmingly common problems is Krüppel-Like Factor 4 (KLF4), a cell regulatory protein crucial to cellular normality and monocyte differentiation. This particular study highlights the effects alcoholism and obesity have on the lung, specifically epithelial cells (L2) and macrophages (AM). The goal of this project is to measure the KLF4 expression in the L2 and AM cells subjected to high ethanol (EtOH) consumption, high glucose consumption, high EtOH and glucose consumption, as well as a healthy control lung in to explain the mechanism behind decreased immune function in these patients.
Issue Date:
May-2015
URI:
http://hdl.handle.net/10675.2/579467
Type:
Thesis
Language:
en_US
Series/Report no.:
Spring; 2015
Appears in Collections:
Honors Program Theses

Full metadata record

DC FieldValue Language
dc.contributor.authorThomas, Amanda Blairen
dc.date.accessioned2015-10-07T20:37:46Zen
dc.date.available2015-10-07T20:37:46Zen
dc.date.issued2015-05en
dc.identifier.urihttp://hdl.handle.net/10675.2/579467en
dc.description.abstractIn the United States today, alcoholism and obesity are increasingly becoming issues for a vast age group from young children to geriatric adults. Alcoholism and obesity have been extensively studied as separate entities that have been proven to change metabolism and cause over-lapping health issues, which prompted us to study them in conjunction with one another, especially in the lungs. One major link between these two alarmingly common problems is Krüppel-Like Factor 4 (KLF4), a cell regulatory protein crucial to cellular normality and monocyte differentiation. This particular study highlights the effects alcoholism and obesity have on the lung, specifically epithelial cells (L2) and macrophages (AM). The goal of this project is to measure the KLF4 expression in the L2 and AM cells subjected to high ethanol (EtOH) consumption, high glucose consumption, high EtOH and glucose consumption, as well as a healthy control lung in to explain the mechanism behind decreased immune function in these patients.en
dc.language.isoen_USen
dc.relation.ispartofseriesSpringen
dc.relation.ispartofseries2015en
dc.rightsCopyright protected. Unauthorized reproduction or use beyond the exceptions granted by the Fair Use clause of U.S. Copyright law may violate federal law.en
dc.subjectAlcoholismen
dc.subjectUnited Statesen
dc.subjectKruppel-Like Transcription Factorsen
dc.subjectObesityen
dc.titlePulmonary Stress in the Alcoholic and Obese Lungen_US
dc.typeThesisen
dc.description.advisorTiana V. Curry-McCoyen
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