Early Development of the Central and Peripheral Nervous Systems Is Coordinated by Wnt and BMP Signals

Hdl Handle:
http://hdl.handle.net/10675.2/561
Title:
Early Development of the Central and Peripheral Nervous Systems Is Coordinated by Wnt and BMP Signals
Authors:
Patthey, Cédric; Gunhaga, Lena; Edlund, Thomas
Abstract:
The formation of functional neural circuits that process sensory information requires coordinated development of the central and peripheral nervous systems derived from neural plate and neural plate border cells, respectively. Neural plate, neural crest and rostral placodal cells are all specified at the late gastrula stage. How the early development of the central and peripheral nervous systems are coordinated remains, however, poorly understood. Previous results have provided evidence that at the late gastrula stage, graded Wnt signals impose rostrocaudal character on neural plate cells, and Bone Morphogenetic Protein (BMP) signals specify olfactory and lens placodal cells at rostral forebrain levels. By using in vitro assays of neural crest and placodal cell differentiation, we now provide evidence that Wnt signals impose caudal character on neural plate border cells at the late gastrula stage, and that under these conditions, BMP signals induce neural crest instead of rostral placodal cells. We also provide evidence that both caudal neural and caudal neural plate border cells become independent of further exposure to Wnt signals at the head fold stage. Thus, the status of Wnt signaling in ectodermal cells at the late gastrula stage regulates the rostrocaudal patterning of both neural plate and neural plate border, providing a coordinated spatial and temporal control of the early development of the central and peripheral nervous systems.
Editors:
Mei, Lin
Citation:
PLoS ONE. 2008 Feb 20; 3(2):e1625
Issue Date:
20-Feb-2008
URI:
http://hdl.handle.net/10675.2/561
DOI:
10.1371/journal.pone.0001625
PubMed ID:
18286182
PubMed Central ID:
PMC2229838
Type:
Article
ISSN:
1932-6203
Appears in Collections:
Department of Neurology: Faculty Research and Presentations

Full metadata record

DC FieldValue Language
dc.contributor.authorPatthey, Cédricen_US
dc.contributor.authorGunhaga, Lenaen_US
dc.contributor.authorEdlund, Thomasen_US
dc.contributor.editorMei, Lin-
dc.date.accessioned2012-10-26T16:26:41Z-
dc.date.available2012-10-26T16:26:41Z-
dc.date.issued2008-02-20en_US
dc.identifier.citationPLoS ONE. 2008 Feb 20; 3(2):e1625en_US
dc.identifier.issn1932-6203en_US
dc.identifier.pmid18286182en_US
dc.identifier.doi10.1371/journal.pone.0001625en_US
dc.identifier.urihttp://hdl.handle.net/10675.2/561-
dc.description.abstractThe formation of functional neural circuits that process sensory information requires coordinated development of the central and peripheral nervous systems derived from neural plate and neural plate border cells, respectively. Neural plate, neural crest and rostral placodal cells are all specified at the late gastrula stage. How the early development of the central and peripheral nervous systems are coordinated remains, however, poorly understood. Previous results have provided evidence that at the late gastrula stage, graded Wnt signals impose rostrocaudal character on neural plate cells, and Bone Morphogenetic Protein (BMP) signals specify olfactory and lens placodal cells at rostral forebrain levels. By using in vitro assays of neural crest and placodal cell differentiation, we now provide evidence that Wnt signals impose caudal character on neural plate border cells at the late gastrula stage, and that under these conditions, BMP signals induce neural crest instead of rostral placodal cells. We also provide evidence that both caudal neural and caudal neural plate border cells become independent of further exposure to Wnt signals at the head fold stage. Thus, the status of Wnt signaling in ectodermal cells at the late gastrula stage regulates the rostrocaudal patterning of both neural plate and neural plate border, providing a coordinated spatial and temporal control of the early development of the central and peripheral nervous systems.en_US
dc.rightsPatthey et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.subjectResearch Articleen_US
dc.subjectDevelopmental Biology/Developmental Molecular Mechanismsen_US
dc.subjectDevelopmental Biology/Molecular Developmenten_US
dc.subjectDevelopmental Biology/Neurodevelopmenten_US
dc.subjectDevelopmental Biology/Pattern Formationen_US
dc.subjectNeuroscience/Neurodevelopmenten_US
dc.titleEarly Development of the Central and Peripheral Nervous Systems Is Coordinated by Wnt and BMP Signalsen_US
dc.typeArticleen_US
dc.identifier.pmcidPMC2229838en_US
dc.contributor.corporatenameDepartment of Neurology-

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