Contribution of â Virus-specific CD8+ Cytotoxic T Cells to Virus Clearance or Pathologic Manifestations of Influenza Virus Infection in a T Cell Receptor Transgenic Mouse Model

Hdl Handle:
http://hdl.handle.net/10675.2/557
Title:
Contribution of â Virus-specific CD8+ Cytotoxic T Cells to Virus Clearance or Pathologic Manifestations of Influenza Virus Infection in a T Cell Receptor Transgenic Mouse Model
Authors:
Moskophidis, Demetrius; Kioussis, Dimitris
Abstract:
The ability of influenza virus to evade immune surveillance by neutralizing antibodies (Abs) directed against its variable surface antigens provides a challenge to the development of effective vaccines. CD8+ cytotoxic T lymphocytes (CTLs) restricted by class I major histocompatibility complex molecules are important in establishing immunity to influenza virus because they recognize internal viral proteins which are conserved between multiple viral strains. In contrast, protective Abs are strain-specific. However, the precise role of effector CD8+ CTLs in protection from influenza virus infection, critical for understanding disease pathogenesis, has not been well defined. In transgenic mice with a very high frequency of antiinfluenza CTL precursors, but without protective Abs, CD8+ CTLs conferred protection against low dose viral challenge, but exacerbated viral pathology and caused mortality at high viral dose. The data suggest a dual role for CD8+ CTLs against influenza, which may present a challenge to the development of effective CTL vaccines. Effector mechanisms used by CD8+ CTLs in orchestrating clearance of virus and recovery from experimental influenza infection, or potentiation of lethal pathology, are discussed.
Citation:
J Exp Med. 1998 Jul 20; 188(2):223-232
Issue Date:
20-Jul-1998
URI:
http://hdl.handle.net/10675.2/557
PubMed ID:
9670035
PubMed Central ID:
PMC2212460
Type:
Article
ISSN:
1540-9538
Appears in Collections:
Institute of Molecular Medicine and Genetics: Faculty Research and Presentations

Full metadata record

DC FieldValue Language
dc.contributor.authorMoskophidis, Demetriusen_US
dc.contributor.authorKioussis, Dimitrisen_US
dc.date.accessioned2012-10-26T16:26:40Z-
dc.date.available2012-10-26T16:26:40Z-
dc.date.issued1998-07-20en_US
dc.identifier.citationJ Exp Med. 1998 Jul 20; 188(2):223-232en_US
dc.identifier.issn1540-9538en_US
dc.identifier.pmid9670035en_US
dc.identifier.urihttp://hdl.handle.net/10675.2/557-
dc.description.abstractThe ability of influenza virus to evade immune surveillance by neutralizing antibodies (Abs) directed against its variable surface antigens provides a challenge to the development of effective vaccines. CD8+ cytotoxic T lymphocytes (CTLs) restricted by class I major histocompatibility complex molecules are important in establishing immunity to influenza virus because they recognize internal viral proteins which are conserved between multiple viral strains. In contrast, protective Abs are strain-specific. However, the precise role of effector CD8+ CTLs in protection from influenza virus infection, critical for understanding disease pathogenesis, has not been well defined. In transgenic mice with a very high frequency of antiinfluenza CTL precursors, but without protective Abs, CD8+ CTLs conferred protection against low dose viral challenge, but exacerbated viral pathology and caused mortality at high viral dose. The data suggest a dual role for CD8+ CTLs against influenza, which may present a challenge to the development of effective CTL vaccines. Effector mechanisms used by CD8+ CTLs in orchestrating clearance of virus and recovery from experimental influenza infection, or potentiation of lethal pathology, are discussed.en_US
dc.subjectArticlesen_US
dc.titleContribution of â Virus-specific CD8+ Cytotoxic T Cells to Virus Clearance or Pathologic Manifestations of Influenza Virus Infection in a T Cell Receptor Transgenic Mouse Modelen_US
dc.typeArticleen_US
dc.identifier.pmcidPMC2212460en_US
dc.contributor.corporatenameInstitute of Molecular Medicine and Genetics-

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