p21B, a variant of p21WAFiycipl, is induced by the p53 family

Hdl Handle:
http://hdl.handle.net/10675.2/552911
Title:
p21B, a variant of p21WAFiycipl, is induced by the p53 family
Authors:
Nozell, Susan
Abstract:
Alternative splicing or expression from an alternate promoter can produce variants of a gene. To determine whether the p21 W*r,/Cipl locus is regulated by these mechanisms, we searched for and found two transcripts, p21B and p21C, that are expressed from an alternate promoter in the first intron of the p21 gene. While p21C encodes the p21 cyclin-dependent kinase inhibitor, p21B encodes a novel protein and is ubiquitously expressed in sixteen human tissues tested. Both p21B and p21C are induced by DNA damage, p53, and p73, and are potentially regulated by a proximal p53 response element in their own promoter. p21B is localized to the Golgi apparatus, and overexpression of p21B inhibits cell proliferation and induces apoptosis. These findings indicate that the p21 locus expresses at least two structurally distinct, but functionally related, variants of the p21 gene from discrete promoters.
Affiliation:
Not Listed
Issue Date:
Dec-2011
URI:
http://hdl.handle.net/10675.2/552911
Additional Links:
http://ezproxy.gru.edu/login?url=http://search.proquest.com/docview/251164023?accountid=12365
Type:
Dissertation
Appears in Collections:
Theses and Dissertations

Full metadata record

DC FieldValue Language
dc.contributor.authorNozell, Susanen
dc.date.accessioned2015-05-15T02:44:36Zen
dc.date.available2015-05-15T02:44:36Zen
dc.date.issued2011-12en
dc.identifier.urihttp://hdl.handle.net/10675.2/552911en
dc.description.abstractAlternative splicing or expression from an alternate promoter can produce variants of a gene. To determine whether the p21 W*r,/Cipl locus is regulated by these mechanisms, we searched for and found two transcripts, p21B and p21C, that are expressed from an alternate promoter in the first intron of the p21 gene. While p21C encodes the p21 cyclin-dependent kinase inhibitor, p21B encodes a novel protein and is ubiquitously expressed in sixteen human tissues tested. Both p21B and p21C are induced by DNA damage, p53, and p73, and are potentially regulated by a proximal p53 response element in their own promoter. p21B is localized to the Golgi apparatus, and overexpression of p21B inhibits cell proliferation and induces apoptosis. These findings indicate that the p21 locus expresses at least two structurally distinct, but functionally related, variants of the p21 gene from discrete promoters.en
dc.relation.urlhttp://ezproxy.gru.edu/login?url=http://search.proquest.com/docview/251164023?accountid=12365en
dc.rightsCopyright protected. Unauthorized reproduction or use beyond the exceptions granted by the Fair Use clause of U.S. Copyright law may violate federal law.en
dc.subjectp21en
dc.subjectGene Alterationen
dc.subjectDNA Damage Responseen
dc.titlep21B, a variant of p21WAFiycipl, is induced by the p53 familyen
dc.typeDissertationen
dc.contributor.departmentNot Listeden
dc.description.advisorChen, Xinbinen
dc.description.committeeAnderson, Mark; Bollag, Wendy; Burns, Christopher; Sadofsky, Moshe; Tuan-Lo, Dorothy; Whitney, Barryen
dc.description.degreeDoctor of Philosophy (Ph.D.)en
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