Characterization of Cardiac L-Type and T-Type Calcium Channels During Normal and Defective Chick Heart Development

Hdl Handle:
http://hdl.handle.net/10675.2/552726
Title:
Characterization of Cardiac L-Type and T-Type Calcium Channels During Normal and Defective Chick Heart Development
Authors:
Nichols, Carol A.
Abstract:
(First Paragraph) The human heart is vital for survival from early in embryonic development throughout life. It begins developing around the third week of gestation from a pair of endocardial tubes that fuse to form a single primitive heart tube. The single-lumen heart tube develops a series of expanded areas and infoldings that divide it into four presumptive chambers. As the embryo grows, the heart begins looping. This looping process serves to bring the four presumptive chambers into the appropriate orientation for septation. The developing heart remodels itself into four separated chambers (two atria or holding chambers, two ventricles or pumping chambers) which provide for separate systemic and pulmonary circulation at birth. In most mammals, oxygenated blood enters the left atrium through four pulmonary veins. The blood is forced into the left ventricle when the left atrium contracts. When the left ventricle contracts, blood is pumped through the aorta and carried throughout the body. Deoxygenated blood returns to the right atrium via the superior and inferior vena cavae. Blood is forced into the right ventricle by contraction of the right atrium. Blood is then pumped through the pulmonary trunk and arteries to the lungs to be re-oxygenated. The four- chambered heart is formed by the eighth week o f gestation. (Larsen, 1997; de la Cruz & Markwald, 1998).
Affiliation:
Not Listed
Issue Date:
Mar-2000
URI:
http://hdl.handle.net/10675.2/552726
Additional Links:
http://ezproxy.gru.edu/login?url=http://search.proquest.com/docview/304635562?accountid=12365
Type:
Dissertation
Appears in Collections:
Theses and Dissertations

Full metadata record

DC FieldValue Language
dc.contributor.authorNichols, Carol A.en
dc.date.accessioned2015-05-13T20:02:40Zen
dc.date.available2015-05-13T20:02:40Zen
dc.date.issued2000-03en
dc.identifier.urihttp://hdl.handle.net/10675.2/552726en
dc.description.abstract(First Paragraph) The human heart is vital for survival from early in embryonic development throughout life. It begins developing around the third week of gestation from a pair of endocardial tubes that fuse to form a single primitive heart tube. The single-lumen heart tube develops a series of expanded areas and infoldings that divide it into four presumptive chambers. As the embryo grows, the heart begins looping. This looping process serves to bring the four presumptive chambers into the appropriate orientation for septation. The developing heart remodels itself into four separated chambers (two atria or holding chambers, two ventricles or pumping chambers) which provide for separate systemic and pulmonary circulation at birth. In most mammals, oxygenated blood enters the left atrium through four pulmonary veins. The blood is forced into the left ventricle when the left atrium contracts. When the left ventricle contracts, blood is pumped through the aorta and carried throughout the body. Deoxygenated blood returns to the right atrium via the superior and inferior vena cavae. Blood is forced into the right ventricle by contraction of the right atrium. Blood is then pumped through the pulmonary trunk and arteries to the lungs to be re-oxygenated. The four- chambered heart is formed by the eighth week o f gestation. (Larsen, 1997; de la Cruz & Markwald, 1998).en
dc.relation.urlhttp://ezproxy.gru.edu/login?url=http://search.proquest.com/docview/304635562?accountid=12365en
dc.rightsCopyright protected. Unauthorized reproduction or use beyond the exceptions granted by the Fair Use clause of U.S. Copyright law may violate federal law.en
dc.subjectHearten
dc.subjectEmbryoen
dc.subjectChickensen
dc.subjectCalcium Channelsen
dc.subjectCalcium Channels, T-Typeen
dc.subjectMuscle Cellsen
dc.titleCharacterization of Cardiac L-Type and T-Type Calcium Channels During Normal and Defective Chick Heart Developmenten
dc.typeDissertationen
dc.contributor.departmentNot Listeden
dc.description.advisorNot Listeden
dc.description.committeeNot Listeden
dc.description.degreeDoctor of Philosophy (Ph.D.)en
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