Characterization of Cervical and Head and Neck Squamous Cell Carcinomas by Proteomic Analysis

Hdl Handle:
http://hdl.handle.net/10675.2/552235
Title:
Characterization of Cervical and Head and Neck Squamous Cell Carcinomas by Proteomic Analysis
Authors:
Merkley, Mark A.
Abstract:
(First Paragraph) The oral cavity, oropharynx, larynx, esophagus, and ano-genital orifices are lined with stratified squamous nonkeratinized epithelium, which forms the barrier between the underlying tissue and the external environment. The proliferative nature of this epithelium, together with its potential exposure to environmental insults such as tobacco carcinogens, alcohol, or oncogenic viruses, makes it susceptible to carcinogenesis. Indeed, carcinomas of stratified squamous nonkeratinized epithelium are among the most common and deadly cancers worldwide. In particular head and neck squamous cell carcinoma and cervical squamous cell carcinoma together account for about 1 million new cases annually, worldwide. These cancers arise from similar tissues and share common risk factors, although they differ in that effective population-based screening exists only for cervical cancer.
Affiliation:
Institute of Molecular Medicine and Genetics
Issue Date:
Jun-2009
URI:
http://hdl.handle.net/10675.2/552235
Additional Links:
http://ezproxy.gru.edu/login?url=https://search.proquest.com/docview/520404146?accountid=12365
Type:
Dissertation
Appears in Collections:
Theses and Dissertations

Full metadata record

DC FieldValue Language
dc.contributor.authorMerkley, Mark A.en
dc.date.accessioned2015-05-05T02:53:20Zen
dc.date.available2015-05-05T02:53:20Zen
dc.date.issued2009-06en
dc.identifier.urihttp://hdl.handle.net/10675.2/552235en
dc.description.abstract(First Paragraph) The oral cavity, oropharynx, larynx, esophagus, and ano-genital orifices are lined with stratified squamous nonkeratinized epithelium, which forms the barrier between the underlying tissue and the external environment. The proliferative nature of this epithelium, together with its potential exposure to environmental insults such as tobacco carcinogens, alcohol, or oncogenic viruses, makes it susceptible to carcinogenesis. Indeed, carcinomas of stratified squamous nonkeratinized epithelium are among the most common and deadly cancers worldwide. In particular head and neck squamous cell carcinoma and cervical squamous cell carcinoma together account for about 1 million new cases annually, worldwide. These cancers arise from similar tissues and share common risk factors, although they differ in that effective population-based screening exists only for cervical cancer.en
dc.relation.urlhttp://ezproxy.gru.edu/login?url=https://search.proquest.com/docview/520404146?accountid=12365en
dc.rightsCopyright protected. Unauthorized reproduction or use beyond the exceptions granted by the Fair Use clause of U.S. Copyright law may violate federal law.en
dc.subjectStratified Squamous Nonkeratinized Epitheliumen
dc.subjectCarcinogenesisen
dc.subjectCanceren
dc.titleCharacterization of Cervical and Head and Neck Squamous Cell Carcinomas by Proteomic Analysisen
dc.typeDissertationen
dc.contributor.departmentInstitute of Molecular Medicine and Geneticsen
dc.description.advisorDynan, William S.en
dc.description.committeeNot Listeden
dc.description.degreeDoctor of Philosophy (Ph.D.)en
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