Regulation of T Cell Immunity by Cells Expressing Indoleamine 2,3-Dioxygenase

Hdl Handle:
http://hdl.handle.net/10675.2/346818
Title:
Regulation of T Cell Immunity by Cells Expressing Indoleamine 2,3-Dioxygenase
Authors:
Keskin, Derin B.
Abstract:
Indoleamine 2,3-dioxygenase (IDO) is an intracellular enzyme, that degrades the essential amino acid tryptophan along the kynurenine pathway. Historically, IDO enzyme function was implicated in antibacterial and antiviral innate immunity, inflammation and antioxidative functions. Recently our lab associated IDO enzyme function with regulation of T cell responses and maintenance of maternal immune tolerance during pregnancy. We hypothesize that cells expressing IDO inhibit T cell responses. We will generate IDO expressing cell lines and IDO transgenic mice to investigate regulation of T cell immune responses by IDO enzyme in this thesis project.
Affiliation:
GRU Cancer Center
Issue Date:
Jul-2002
URI:
http://hdl.handle.net/10675.2/346818
Additional Links:
http://ezproxy.gru.edu/login?url=http://search.proquest.com/docview/305461798?accountid=12365
Type:
Dissertation
Appears in Collections:
Theses and Dissertations

Full metadata record

DC FieldValue Language
dc.contributor.authorKeskin, Derin B.en
dc.date.accessioned2015-03-18T01:51:27Zen
dc.date.available2015-03-18T01:51:27Zen
dc.date.issued2002-07en
dc.identifier.urihttp://hdl.handle.net/10675.2/346818en
dc.description.abstractIndoleamine 2,3-dioxygenase (IDO) is an intracellular enzyme, that degrades the essential amino acid tryptophan along the kynurenine pathway. Historically, IDO enzyme function was implicated in antibacterial and antiviral innate immunity, inflammation and antioxidative functions. Recently our lab associated IDO enzyme function with regulation of T cell responses and maintenance of maternal immune tolerance during pregnancy. We hypothesize that cells expressing IDO inhibit T cell responses. We will generate IDO expressing cell lines and IDO transgenic mice to investigate regulation of T cell immune responses by IDO enzyme in this thesis project.en
dc.relation.urlhttp://ezproxy.gru.edu/login?url=http://search.proquest.com/docview/305461798?accountid=12365en
dc.rightsCopyright protected. Unauthorized reproduction or use beyond the exceptions granted by the Fair Use clause of U.S. Copyright law may violate federal law.en
dc.subjectTryptophanen
dc.subjectIDOen
dc.subjectT cellen
dc.subjectindoleamine 2,3 dioxygenaseen
dc.titleRegulation of T Cell Immunity by Cells Expressing Indoleamine 2,3-Dioxygenaseen
dc.typeDissertationen
dc.contributor.departmentGRU Cancer Centeren
dc.description.advisorMellor, Andrewen
dc.description.committeeMunn, David; Hill, William; Ignatowics, Leshek; Iwashima, Makioen
dc.description.degreeDoctor of Philosophy (Ph.D.)en
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