Effect of Phorbol Esters on the Regulation of Rat Decidual Cell Regression

Hdl Handle:
http://hdl.handle.net/10675.2/345727
Title:
Effect of Phorbol Esters on the Regulation of Rat Decidual Cell Regression
Authors:
George, Philip
Abstract:
Specific Aims: 1. To determine the decidual stromal cell cycle by analysis of mitotic figures, PCNA expression and flow cytometry and examine its correlation with PKC enzyme activity in stromal cells at 8, 10, 12, 14, and 17 days of pregnancy. 2. To determine the changes induced by the administration of phorbol esters on mitotic figures, PCNA expression, flow cytometry and PKC enzyme activity in stromal cells and examine the correlation between cell cycle changes with PKC enzyme activity. 3. To determine the effects of phorbol esters on ER and PR mRNAs and progesterone binding sites at day 10 and day 14 of pregnancy, the time of decidual stromal cell proliferation and regression respectively. 4. To determine the effect of antiprogestin (RU 486) on PKC enxyme activity in stromal cells at day 10 of pregnancy.
Affiliation:
Not Listed
Issue Date:
Dec-1997
URI:
http://hdl.handle.net/10675.2/345727
Additional Links:
http://ezproxy.gru.edu/login?url=http://search.proquest.com/docview/304381229?accountid=12365
Type:
Dissertation
Appears in Collections:
Theses and Dissertations

Full metadata record

DC FieldValue Language
dc.contributor.authorGeorge, Philipen
dc.date.accessioned2015-02-27T20:45:57Z-
dc.date.available2015-02-27T20:45:57Z-
dc.date.issued1997-12-
dc.identifier.urihttp://hdl.handle.net/10675.2/345727-
dc.description.abstractSpecific Aims: 1. To determine the decidual stromal cell cycle by analysis of mitotic figures, PCNA expression and flow cytometry and examine its correlation with PKC enzyme activity in stromal cells at 8, 10, 12, 14, and 17 days of pregnancy. 2. To determine the changes induced by the administration of phorbol esters on mitotic figures, PCNA expression, flow cytometry and PKC enzyme activity in stromal cells and examine the correlation between cell cycle changes with PKC enzyme activity. 3. To determine the effects of phorbol esters on ER and PR mRNAs and progesterone binding sites at day 10 and day 14 of pregnancy, the time of decidual stromal cell proliferation and regression respectively. 4. To determine the effect of antiprogestin (RU 486) on PKC enxyme activity in stromal cells at day 10 of pregnancy.en
dc.relation.urlhttp://ezproxy.gru.edu/login?url=http://search.proquest.com/docview/304381229?accountid=12365en
dc.rightsCopyright protected. Unauthorized reproduction or use beyond the exceptions granted by the Fair Use clause of U.S. Copyright law may violate federal law.en
dc.subjectPKCen
dc.subjectPCNAen
dc.subjectDecidual Stromal Cell Cycleen
dc.subjectPregnancyen
dc.subjectPhorbol Estersen
dc.subjectantiprogestinen
dc.subjectRU 486en
dc.titleEffect of Phorbol Esters on the Regulation of Rat Decidual Cell Regressionen
dc.typeDissertationen
dc.contributor.departmentNot Listeden
dc.description.advisorOgle, Thomas F.en
dc.description.committeeNot Listeden
dc.description.degreeDoctor of Philosophy (Ph.D.)en
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