Molecular and Functional Characterization of the Carnitine Transporter OCTN2 and the Dicarboxylate Transporter NADC3

Hdl Handle:
http://hdl.handle.net/10675.2/345707
Title:
Molecular and Functional Characterization of the Carnitine Transporter OCTN2 and the Dicarboxylate Transporter NADC3
Authors:
George, Ronald L.
Abstract:
The present project focused on the two transport systems. OCTN2 and NaDC3, which play a role in the transport of acetyl moieties (acetylcarnitine by OCTN2 and Nacetylaspartate by NaDC3). To better understand the physiological, biochemical and clinical significance of these two transporters, we proposed and completed the following specific aims: 1. Define the structure-function relationship of OCTN2. 2. Investigate the interrelationship between OCTN2 expression, function and PPARy. 3. Clone and functionally characterize the mouse homolog of NaDC3 and determine its expression in ocular tissues. 4. Construct a knockout vector, NaDC3-pKO, based upon the intron-exon organization of the mouse NaDC3 gene.
Affiliation:
Not Listed
Issue Date:
Mar-2002
URI:
http://hdl.handle.net/10675.2/345707
Additional Links:
http://ezproxy.gru.edu/login?url=http://search.proquest.com/docview/305463997?accountid=12365
Type:
Dissertation
Appears in Collections:
Theses and Dissertations

Full metadata record

DC FieldValue Language
dc.contributor.authorGeorge, Ronald L.en
dc.date.accessioned2015-02-27T22:58:03Z-
dc.date.available2015-02-27T22:58:03Z-
dc.date.issued2002-03-
dc.identifier.urihttp://hdl.handle.net/10675.2/345707-
dc.description.abstractThe present project focused on the two transport systems. OCTN2 and NaDC3, which play a role in the transport of acetyl moieties (acetylcarnitine by OCTN2 and Nacetylaspartate by NaDC3). To better understand the physiological, biochemical and clinical significance of these two transporters, we proposed and completed the following specific aims: 1. Define the structure-function relationship of OCTN2. 2. Investigate the interrelationship between OCTN2 expression, function and PPARy. 3. Clone and functionally characterize the mouse homolog of NaDC3 and determine its expression in ocular tissues. 4. Construct a knockout vector, NaDC3-pKO, based upon the intron-exon organization of the mouse NaDC3 gene.en
dc.relation.urlhttp://ezproxy.gru.edu/login?url=http://search.proquest.com/docview/305463997?accountid=12365en
dc.rightsCopyright protected. Unauthorized reproduction or use beyond the exceptions granted by the Fair Use clause of U.S. Copyright law may violate federal law.en
dc.subjectOCTN2en
dc.subjectNaDC3en
dc.subjectPPARyen
dc.subjectAcetyl Moietiesen
dc.titleMolecular and Functional Characterization of the Carnitine Transporter OCTN2 and the Dicarboxylate Transporter NADC3en
dc.typeDissertationen
dc.contributor.departmentNot Listeden
dc.description.advisorGanapathy, Vadivelen
dc.description.committeeLeibach, F.H.; Prasad, P.D.; Smith, S.; Webb, R.C.en
dc.description.degreeDoctor of Philosophy (Ph.D.)en
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