Impaired Cognition in Spontaneously Hypertensive Rats: Role of Central Cholinergic Receptors

Hdl Handle:
http://hdl.handle.net/10675.2/345391
Title:
Impaired Cognition in Spontaneously Hypertensive Rats: Role of Central Cholinergic Receptors
Authors:
Gattu, Mahanandeeshwar
Abstract:
The cognitive impairment exhibited by the spontaneously hypertensive strain of rat is due to a reduction in the expression fo central cholinergic receptors. Therefore, the specific aims of this study are: 1. To determine whether the hypertensive state present in SHR contributes to impaired performance on spatial memory tasks. 2. To determine whether SHR exhibit altered expression of cholinergic receptor subtypes in brain regions important for memory function 3. To determine whether the decreased expression of central nicotinic-cholinergic receptors observed in SHR have functional significance.
Affiliation:
Not Listed
Issue Date:
Sep-1996
URI:
http://hdl.handle.net/10675.2/345391
Additional Links:
http://ezproxy.augusta.edu/login?url=http://search.proquest.com/docview/304337621?accountid=12365
Type:
Dissertation
Appears in Collections:
Theses and Dissertations

Full metadata record

DC FieldValue Language
dc.contributor.authorGattu, Mahanandeeshwaren
dc.date.accessioned2015-02-26T04:42:27Z-
dc.date.available2015-02-26T04:42:27Z-
dc.date.issued1996-09-
dc.identifier.urihttp://hdl.handle.net/10675.2/345391-
dc.description.abstractThe cognitive impairment exhibited by the spontaneously hypertensive strain of rat is due to a reduction in the expression fo central cholinergic receptors. Therefore, the specific aims of this study are: 1. To determine whether the hypertensive state present in SHR contributes to impaired performance on spatial memory tasks. 2. To determine whether SHR exhibit altered expression of cholinergic receptor subtypes in brain regions important for memory function 3. To determine whether the decreased expression of central nicotinic-cholinergic receptors observed in SHR have functional significance.en
dc.relation.urlhttp://ezproxy.augusta.edu/login?url=http://search.proquest.com/docview/304337621?accountid=12365en
dc.rightsCopyright protected. Unauthorized reproduction or use beyond the exceptions granted by the Fair Use clause of U.S. Copyright law may violate federal law.en
dc.subjectHypertensionen
dc.subjectCognitionen
dc.subjectCholinergicen
dc.titleImpaired Cognition in Spontaneously Hypertensive Rats: Role of Central Cholinergic Receptorsen
dc.typeDissertationen
dc.contributor.departmentNot Listeden
dc.description.advisorBuccafusco, Jerry J.en
dc.description.committeeCaldwell, Robert W.; Fuchs, Leslie C.; Hill, William D.; Jackson, William J.; Mozaffari, Mohmood S.en
dc.description.degreeDoctor of Philosophy (Ph.D.)en
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