Cellular and Immunocytochemical Response to Mandibular Distraction Using an Implanted Lengthening Device

Hdl Handle:
http://hdl.handle.net/10675.2/345124
Title:
Cellular and Immunocytochemical Response to Mandibular Distraction Using an Implanted Lengthening Device
Authors:
Elbokle, Nadar N
Abstract:
Distraction osteogenesis (DO) is a biologic process that generates new bone between surfaces of bone segments, which are gradually separated by traction forces. It is a uniquely effective method with multiple applications in the craniofacial region. This concept has been the basis of all bone-lengthening operations; it involved an osteotomy of the shortened bone and an external/internal fixator device, which slowly elongates the bone to its new dimension while a bony callus is being formed at the side to distraction. The biology of DO is similar to callus fracture healing. The bony regenerate passes through the same phases: formation of a collagen fibril template, mineralization, bony union and finally remodeling. The mechanisms by which the mechanical stresses applied to the bone tissue cause the cells to proliferate and form new bone are not well understood. More studies are needed to understand the cellular events underlying DO and the effects of the strains applied during DO on cellular proliferation and mineral apposition.
Affiliation:
Department of Oral Biology
Issue Date:
2004
URI:
http://hdl.handle.net/10675.2/345124
Additional Links:
http://ezproxy.gru.edu/login?url=http://search.proquest.com/docview/305095305?accountid=12365
Type:
Dissertation
Appears in Collections:
Theses and Dissertations

Full metadata record

DC FieldValue Language
dc.contributor.authorElbokle, Nadar Nen
dc.date.accessioned2015-02-24T02:15:36Z-
dc.date.available2015-02-24T02:15:36Z-
dc.date.issued2004-
dc.identifier.urihttp://hdl.handle.net/10675.2/345124-
dc.description.abstractDistraction osteogenesis (DO) is a biologic process that generates new bone between surfaces of bone segments, which are gradually separated by traction forces. It is a uniquely effective method with multiple applications in the craniofacial region. This concept has been the basis of all bone-lengthening operations; it involved an osteotomy of the shortened bone and an external/internal fixator device, which slowly elongates the bone to its new dimension while a bony callus is being formed at the side to distraction. The biology of DO is similar to callus fracture healing. The bony regenerate passes through the same phases: formation of a collagen fibril template, mineralization, bony union and finally remodeling. The mechanisms by which the mechanical stresses applied to the bone tissue cause the cells to proliferate and form new bone are not well understood. More studies are needed to understand the cellular events underlying DO and the effects of the strains applied during DO on cellular proliferation and mineral apposition.en
dc.relation.urlhttp://ezproxy.gru.edu/login?url=http://search.proquest.com/docview/305095305?accountid=12365en
dc.rightsCopyright protected. Unauthorized reproduction or use beyond the exceptions granted by the Fair Use clause of U.S. Copyright law may violate federal law.en
dc.subjectOsteogenesisen
dc.subjectDistractionen
dc.subjectGrowth Factor ben
dc.subjectPCNAen
dc.titleCellular and Immunocytochemical Response to Mandibular Distraction Using an Implanted Lengthening Deviceen
dc.typeDissertationen
dc.contributor.departmentDepartment of Oral Biologyen
dc.description.advisorSharawy, Mohamed M.en
dc.description.committeeYu, Jack; Pashley, David; Lewis, Jill; Borke, Jamesen
dc.description.degreeDoctor of Philosophy (Ph.D.)en
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