Mechanisms of Neuroprotection by Estrogen and Selective Estrogen Receptor Modulators

Hdl Handle:
http://hdl.handle.net/10675.2/344582
Title:
Mechanisms of Neuroprotection by Estrogen and Selective Estrogen Receptor Modulators
Authors:
Dhandapani, Krishnan M.
Abstract:
Specific Aim #1: To determine whether 17b-E2 and SERMs directly influence neuronal survival. Specific Aim #2: To determine whether astrocyte-derived TGF-b protects neurons from cell death. Specific Aim #3: To determine whether 17b-E2 or SERMs regulate the release of TGF-b from astrocytes. Specific Aim #4:To elucidate the mechanism of TGF-b mediated neuroprotection in GT1-7 Neurons. Specific Aim #5: To identify genes potentially mediating the neuroprotective effects of 17b-E2 and/or tamoxifen through the use of high density gene chip arrays.
Affiliation:
Institute of Molecular Medicine and Genetics
Issue Date:
Mar-2003
URI:
http://hdl.handle.net/10675.2/344582
Additional Links:
http://ezproxy.gru.edu/login?url=http://search.proquest.com/docview/288313688?accountid=12365
Type:
Dissertation
Appears in Collections:
Theses and Dissertations

Full metadata record

DC FieldValue Language
dc.contributor.authorDhandapani, Krishnan M.en
dc.date.accessioned2015-02-19T03:35:18Z-
dc.date.available2015-02-19T03:35:18Z-
dc.date.issued2003-03-
dc.identifier.urihttp://hdl.handle.net/10675.2/344582-
dc.description.abstractSpecific Aim #1: To determine whether 17b-E2 and SERMs directly influence neuronal survival. Specific Aim #2: To determine whether astrocyte-derived TGF-b protects neurons from cell death. Specific Aim #3: To determine whether 17b-E2 or SERMs regulate the release of TGF-b from astrocytes. Specific Aim #4:To elucidate the mechanism of TGF-b mediated neuroprotection in GT1-7 Neurons. Specific Aim #5: To identify genes potentially mediating the neuroprotective effects of 17b-E2 and/or tamoxifen through the use of high density gene chip arrays.en
dc.relation.urlhttp://ezproxy.gru.edu/login?url=http://search.proquest.com/docview/288313688?accountid=12365en
dc.rightsCopyright protected. Unauthorized reproduction or use beyond the exceptions granted by the Fair Use clause of U.S. Copyright law may violate federal law.en
dc.subject17b-E2en
dc.subjectSERMSen
dc.subjectNeuroprotectionen
dc.subjectNeurodegenerationen
dc.subjectGenderen
dc.titleMechanisms of Neuroprotection by Estrogen and Selective Estrogen Receptor Modulatorsen
dc.typeDissertationen
dc.contributor.departmentInstitute of Molecular Medicine and Geneticsen
dc.description.advisorBrann, Darrellen
dc.description.committeeMahesh, Virendra; Prasad, Puttar; Lewis, Deborah; Carroll, Jamesen
dc.description.degreeDoctor of Philosophy (Ph.D.)en
All Items in Scholarly Commons are protected by copyright, with all rights reserved, unless otherwise indicated.