Progesterone Regulation of Proliferation and Regression of Rat Decidua Basalis

Hdl Handle:
http://hdl.handle.net/10675.2/344542
Title:
Progesterone Regulation of Proliferation and Regression of Rat Decidua Basalis
Authors:
Dai, Donghai
Abstract:
During implantation mesometrial cells o f the uterine stroma become decidualized under the coordinate actions of progesterone (P4 ) and estrogen (E) [1,2]. This process is characterized by transformation o f phenotype and stromal cell proliferation between Days 8-12 of gestation, resulting ultimately in the formation o f the decidua basalis (DB) [3,4], By Day 14. however, the DB begins to regress and a reduced layer o f stromal cells persists to the end of pregnancy [5.6]. The regression of DB is accompanied by development o f two other layers, namely junctional zone (JZ) and labyrinth zone (LZ), which are fetal parts of the placenta and morphologically become predominant at the end stages o f pregnancy. Although the morphological changes have been well documented and numerous functions have been revealed for DB [3-8], the mechanism and factors involved in the regulation of proliferation and regression o f DB have not been elucidated. The transition of DB from proliferation to regression occurs in such a delicate way that the morphological integrity and functional competence of the DB and placenta are maintained even though stromal cells are being lost. The objective o f this study was to identify the intracellular signals initially favoring proliferation and synthetic processes and those promoting remodeling and regression as pregnancy progresses.
Affiliation:
Not Listed
Issue Date:
Jul-1998
URI:
http://hdl.handle.net/10675.2/344542
Additional Links:
http://ezproxy.gru.edu/login?url=http://search.proquest.com/docview/304505268?accountid=12365
Type:
Dissertation
Appears in Collections:
Theses and Dissertations

Full metadata record

DC FieldValue Language
dc.contributor.authorDai, Donghaien
dc.date.accessioned2015-02-17T23:39:33Z-
dc.date.available2015-02-17T23:39:33Z-
dc.date.issued1998-07-
dc.identifier.urihttp://hdl.handle.net/10675.2/344542-
dc.description.abstractDuring implantation mesometrial cells o f the uterine stroma become decidualized under the coordinate actions of progesterone (P4 ) and estrogen (E) [1,2]. This process is characterized by transformation o f phenotype and stromal cell proliferation between Days 8-12 of gestation, resulting ultimately in the formation o f the decidua basalis (DB) [3,4], By Day 14. however, the DB begins to regress and a reduced layer o f stromal cells persists to the end of pregnancy [5.6]. The regression of DB is accompanied by development o f two other layers, namely junctional zone (JZ) and labyrinth zone (LZ), which are fetal parts of the placenta and morphologically become predominant at the end stages o f pregnancy. Although the morphological changes have been well documented and numerous functions have been revealed for DB [3-8], the mechanism and factors involved in the regulation of proliferation and regression o f DB have not been elucidated. The transition of DB from proliferation to regression occurs in such a delicate way that the morphological integrity and functional competence of the DB and placenta are maintained even though stromal cells are being lost. The objective o f this study was to identify the intracellular signals initially favoring proliferation and synthetic processes and those promoting remodeling and regression as pregnancy progresses.en
dc.relation.urlhttp://ezproxy.gru.edu/login?url=http://search.proquest.com/docview/304505268?accountid=12365en
dc.rightsCopyright protected. Unauthorized reproduction or use beyond the exceptions granted by the Fair Use clause of U.S. Copyright law may violate federal law.en
dc.subjectEpidermal Growth Factor Receptoren
dc.subjectProgesteroneen
dc.subjectProgesterone Receptoren
dc.subjectEstrogenen
dc.subjectEstrogen Receptoren
dc.titleProgesterone Regulation of Proliferation and Regression of Rat Decidua Basalisen
dc.typeDissertationen
dc.contributor.departmentNot Listeden
dc.description.advisorOgle, Thomas F.en
dc.description.committeeMahesh, Virendra B.; Mills, Thomas M.; O'Conner, James L.; Borke, James L.en
dc.description.degreeDoctor of Philosophy (Ph.D.)en
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