GPR109A as a Link Between Gut Flora and Colonic Health

Hdl Handle:
http://hdl.handle.net/10675.2/344541
Title:
GPR109A as a Link Between Gut Flora and Colonic Health
Authors:
Cresci, Gail A.
Abstract:
Hypothesis: The bacterial fermentation product butyrate, produced from undigested dietary polysaccharides by the normal colonic microbiota, is a ligand for GPR109A and plays an active role in epithelial biology and function in the intestinal tract. According to this hypothesis, the normal colonic microbiota promote intestinal and colonic health, and GPR109A provides a link between the gut flora and colonic/intestinal health. Aim 1: Study the expression and subcellular localization of GPR109A in intestinal epithelial cells in mice and humans. Aim 2: Compare the expression of GPR109A in the intestinal tract between control mice and germ-free mice. Aim 3: Investigate the physiologic functions of GPR109A in intestinal and colonic epithelial cells.
Affiliation:
Not Listed
Issue Date:
Nov-2009
URI:
http://hdl.handle.net/10675.2/344541
Additional Links:
http://ezproxy.gru.edu/login?url=http://search.proquest.com/docview/305056913?accountid=12365
Type:
Dissertation
Appears in Collections:
Theses and Dissertations

Full metadata record

DC FieldValue Language
dc.contributor.authorCresci, Gail A.en
dc.date.accessioned2015-02-17T22:57:15Z-
dc.date.available2015-02-17T22:57:15Z-
dc.date.issued2009-11-
dc.identifier.urihttp://hdl.handle.net/10675.2/344541-
dc.description.abstractHypothesis: The bacterial fermentation product butyrate, produced from undigested dietary polysaccharides by the normal colonic microbiota, is a ligand for GPR109A and plays an active role in epithelial biology and function in the intestinal tract. According to this hypothesis, the normal colonic microbiota promote intestinal and colonic health, and GPR109A provides a link between the gut flora and colonic/intestinal health. Aim 1: Study the expression and subcellular localization of GPR109A in intestinal epithelial cells in mice and humans. Aim 2: Compare the expression of GPR109A in the intestinal tract between control mice and germ-free mice. Aim 3: Investigate the physiologic functions of GPR109A in intestinal and colonic epithelial cells.en
dc.relation.urlhttp://ezproxy.gru.edu/login?url=http://search.proquest.com/docview/305056913?accountid=12365en
dc.rightsCopyright protected. Unauthorized reproduction or use beyond the exceptions granted by the Fair Use clause of U.S. Copyright law may violate federal law.en
dc.subjectGastrointestinal Tracten
dc.subjectGPR109Aen
dc.subjectColonen
dc.subjectButyrateen
dc.titleGPR109A as a Link Between Gut Flora and Colonic Healthen
dc.typeDissertationen
dc.contributor.departmentNot Listeden
dc.description.advisorGanapathy, Vadivelen
dc.description.committeeMellinger, John; Prasad, Puttur; Smith, Sylvia; Thompson, Stuarten
dc.description.degreeDoctor of Philosophy (Ph.D.)en
All Items in Scholarly Commons are protected by copyright, with all rights reserved, unless otherwise indicated.