Studies on NF-kB Activation During Reperfusion Injury Following Reversible Acute Ischemic Stroke

Hdl Handle:
http://hdl.handle.net/10675.2/344485
Title:
Studies on NF-kB Activation During Reperfusion Injury Following Reversible Acute Ischemic Stroke
Authors:
Chen, Qiang
Abstract:
Specific Aim # 1. To investigate whether reoxvsenation o f hypoxic cells results in the activation o f NF-kB in the HBMEC model. I f NF-kB is activated, identify the Rel family proteins in the activated NF-kB. Specific Aim # 2: To investigate whether reperfusion o f the ischemic brain tissue results in the activation o f NF-kB in the rat stroke model. I f NF-kB is activated, identify the Rel family proteins in the activated NF-kB. Specific Aim # 3: To test the efficacy o f antioxidants /NAC. PDTC) on the inhibition o f NF-kB activation following TNF-a-treatment or kwoxiaJreperfusion in the HBMEC model.
Affiliation:
Department of Cellular Biology and Anatomy
Issue Date:
Oct-1998
URI:
http://hdl.handle.net/10675.2/344485
Additional Links:
http://ezproxy.augusta.edu/login?url=http://search.proquest.com/docview/304463516?accountid=12365
Type:
Dissertation
Appears in Collections:
Department of Cellular Biology and Anatomy Theses and Dissertations; Theses and Dissertations

Full metadata record

DC FieldValue Language
dc.contributor.authorChen, Qiangen
dc.date.accessioned2015-02-16T20:56:36Z-
dc.date.available2015-02-16T20:56:36Z-
dc.date.issued1998-10-
dc.identifier.urihttp://hdl.handle.net/10675.2/344485-
dc.description.abstractSpecific Aim # 1. To investigate whether reoxvsenation o f hypoxic cells results in the activation o f NF-kB in the HBMEC model. I f NF-kB is activated, identify the Rel family proteins in the activated NF-kB. Specific Aim # 2: To investigate whether reperfusion o f the ischemic brain tissue results in the activation o f NF-kB in the rat stroke model. I f NF-kB is activated, identify the Rel family proteins in the activated NF-kB. Specific Aim # 3: To test the efficacy o f antioxidants /NAC. PDTC) on the inhibition o f NF-kB activation following TNF-a-treatment or kwoxiaJreperfusion in the HBMEC model.en
dc.relation.urlhttp://ezproxy.augusta.edu/login?url=http://search.proquest.com/docview/304463516?accountid=12365en
dc.rightsCopyright protected. Unauthorized reproduction or use beyond the exceptions granted by the Fair Use clause of U.S. Copyright law may violate federal law.en
dc.rightsAn error occurred on the license name.*
dc.rights.uriAn error occurred getting the license - uri.*
dc.subjectAcute Ischemic Strokeen
dc.subjectCytokinesen
dc.subjectReperfusion Injuryen
dc.subjectMolecule Therapyen
dc.subjectThiol Containing Antioxidanten
dc.subjectProteasome Inhibitorsen
dc.titleStudies on NF-kB Activation During Reperfusion Injury Following Reversible Acute Ischemic Strokeen
dc.typeDissertationen
dc.contributor.departmentDepartment of Cellular Biology and Anatomyen
dc.description.advisorHoward, Eugene F.en
dc.description.committeeCarroll, James E.; Hess, David C.; Lanclos, Kenneth F.; Lapp, David; Scott, Daviden
dc.description.degreeDoctor of Philosophy (Ph.D.)en
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