Characterization of the Biphasic Effect of 17 B-Estradiol on Fish Responsiveness in Rat Granulosa Cells

Hdl Handle:
http://hdl.handle.net/10675.2/344382
Title:
Characterization of the Biphasic Effect of 17 B-Estradiol on Fish Responsiveness in Rat Granulosa Cells
Authors:
Cannady, William E.
Abstract:
It has been well documented that the duration of estrogen exposure regulates the release of gonadotropins from the hypothalamic-anterior pituitary axis. However, there are conflicting data as to the effects of estrogen in the ovary. Within the ovary, cyclic exposure to estrogen initiates follicle growth and development, which ultimately results in the formation of follicles capable of ovulating. However, some studies have shown that prolonged estrogen exposure may inhibit follicle development. Therefore characterizing this biphasic action of estrogen on ovarian follicle development will provide an explanation for these previously conflicting results. The following hypothesis is proposed: Short durations of estradiol exposure synergizes with follicle stimulating hormone by inducing FSH receptor; longer durations of estradiol not only decrease circulating levels of FSH but also suppress the responsiveness of granulosa cells to FSH.
Affiliation:
Department of Cellular Biology and Anatomy
Issue Date:
Jul-1998
URI:
http://hdl.handle.net/10675.2/344382
Additional Links:
http://ezproxy.augusta.edu/login?url=http://search.proquest.com/docview/304463554?accountid=12365
Type:
Dissertation
Appears in Collections:
Department of Cellular Biology and Anatomy Theses and Dissertations; Theses and Dissertations

Full metadata record

DC FieldValue Language
dc.contributor.authorCannady, William E.en
dc.date.accessioned2015-02-12T03:55:09Z-
dc.date.available2015-02-12T03:55:09Z-
dc.date.issued1998-07-
dc.identifier.urihttp://hdl.handle.net/10675.2/344382-
dc.description.abstractIt has been well documented that the duration of estrogen exposure regulates the release of gonadotropins from the hypothalamic-anterior pituitary axis. However, there are conflicting data as to the effects of estrogen in the ovary. Within the ovary, cyclic exposure to estrogen initiates follicle growth and development, which ultimately results in the formation of follicles capable of ovulating. However, some studies have shown that prolonged estrogen exposure may inhibit follicle development. Therefore characterizing this biphasic action of estrogen on ovarian follicle development will provide an explanation for these previously conflicting results. The following hypothesis is proposed: Short durations of estradiol exposure synergizes with follicle stimulating hormone by inducing FSH receptor; longer durations of estradiol not only decrease circulating levels of FSH but also suppress the responsiveness of granulosa cells to FSH.en
dc.relation.urlhttp://ezproxy.augusta.edu/login?url=http://search.proquest.com/docview/304463554?accountid=12365en
dc.rightsCopyright protected. Unauthorized reproduction or use beyond the exceptions granted by the Fair Use clause of U.S. Copyright law may violate federal law.en
dc.subjectReproductive Cycleen
dc.subjectOvariesen
dc.subjectFSHen
dc.subjectOvarian Follicle Growthen
dc.subjectGranulosa Cellsen
dc.subjectEstrogenen
dc.titleCharacterization of the Biphasic Effect of 17 B-Estradiol on Fish Responsiveness in Rat Granulosa Cellsen
dc.typeDissertationen
dc.contributor.departmentDepartment of Cellular Biology and Anatomyen
dc.description.advisorMills, T. M.en
dc.description.committeeMahesh, V. B.; Brann, D. W.; Ogle, T. F.; Stoming, T. A.en
dc.description.degreeDoctor of Philosophy (Ph.D.)en
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