Bioactivity and Mechanism of Action of Resveratrol, A Polyhenolic Phytoalexin, in Sickle Cell Disease

Hdl Handle:
http://hdl.handle.net/10675.2/337555
Title:
Bioactivity and Mechanism of Action of Resveratrol, A Polyhenolic Phytoalexin, in Sickle Cell Disease
Authors:
Agyekum, Davies G.
Abstract:
The primary goal of this research was to evaluate the fetal hemoglobin (HbF)- inducing efficacy of resveratrol (RSV), a plant polyphenol, in relevant in vitro systems, a preclinical mouse model of sickle cell disease (SCD) and to determ ine its mechanism of action. An overview of the public health impact of SCD, the molecular pathogenesis of the disease and our current understanding of the fetal-to-adult hemoglobin switch are discussed in detail below. Additionally, the roles of erythroid Kruppel-like factor 1 (KLF1) and B-cell lymphoma 11A (BCL11A) in silencing the gene responsible for fetal hemoglobin are discussed, followed by a description of experimental models used to study sickle cell disease. Lastly, the properties and applications of RSV in relevant disease models are discussed, followed by a description of the objectives and specific aims of this study.
Affiliation:
Department of Anesthesiology and Perioperative Medicine
Issue Date:
Jul-2013
URI:
http://hdl.handle.net/10675.2/337555
Additional Links:
http://ezproxy.gru.edu/login?url=http://search.proquest.com/docview/1448690829?accountid=12365
Type:
Dissertation
Appears in Collections:
Theses and Dissertations

Full metadata record

DC FieldValue Language
dc.contributor.authorAgyekum, Davies G.en
dc.date.accessioned2014-12-22T20:53:12Z-
dc.date.available2014-12-22T20:53:12Z-
dc.date.issued2013-07-
dc.identifier.urihttp://hdl.handle.net/10675.2/337555-
dc.description.abstractThe primary goal of this research was to evaluate the fetal hemoglobin (HbF)- inducing efficacy of resveratrol (RSV), a plant polyphenol, in relevant in vitro systems, a preclinical mouse model of sickle cell disease (SCD) and to determ ine its mechanism of action. An overview of the public health impact of SCD, the molecular pathogenesis of the disease and our current understanding of the fetal-to-adult hemoglobin switch are discussed in detail below. Additionally, the roles of erythroid Kruppel-like factor 1 (KLF1) and B-cell lymphoma 11A (BCL11A) in silencing the gene responsible for fetal hemoglobin are discussed, followed by a description of experimental models used to study sickle cell disease. Lastly, the properties and applications of RSV in relevant disease models are discussed, followed by a description of the objectives and specific aims of this study.en
dc.relation.urlhttp://ezproxy.gru.edu/login?url=http://search.proquest.com/docview/1448690829?accountid=12365en
dc.rightsCopyright protected. Unauthorized reproduction or use beyond the exceptions granted by the Fair Use clause of U.S. Copyright law may violate federal law.en
dc.titleBioactivity and Mechanism of Action of Resveratrol, A Polyhenolic Phytoalexin, in Sickle Cell Diseaseen
dc.typeDissertationen
dc.contributor.departmentDepartment of Anesthesiology and Perioperative Medicineen
dc.description.advisorMeiler, Steffenen
dc.description.committeeMcCluskey, Lynnette; Dhandapani, Krishnan; Bollag, Wendy; Pollock, Jenniferen
dc.description.degreeDoctor of Philosophy (Ph.D.)en
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