Novel Peroxisomal Localization of Sirtuin 3 and its Biological Implications

Hdl Handle:
http://hdl.handle.net/10675.2/325521
Title:
Novel Peroxisomal Localization of Sirtuin 3 and its Biological Implications
Authors:
Padia, Ravi N.
Abstract:
Post translational modifications (PTMs) such as phosphorylation, acetylation, ubiquitination, methylation, SUMOylation etc. serve to add another level of complexity and functional diversity to the proteome. These PTMs serve to generate a distinct signal which can then regulate the functionality of the protein harboring one or more of these PTMs and hence ultimately regulating the associated signaling/biological pathway. Some of the ways in which PTMs can bring about the change in the functionality of proteome is by influencing the sub-cellular localization of proteins, protein-protein, protein-DNA, protein-RNA interactions, activity of enzymes, protein turnover, oligomerization of proteins etc. Further, a combination of two or more PTMs can bring about another layer of regulation where presence of a particular combination of PTMs is obligatory to elicit the regulatory message (Yang and Seto 2008a).
Issue Date:
Apr-2014
URI:
http://hdl.handle.net/10675.2/325521
Additional Links:
http://ezproxy.gru.edu/login?url=http://search.proquest.com/docview/1527018534?accountid=12365
Type:
Dissertation
Language:
en
Appears in Collections:
Theses and Dissertations

Full metadata record

DC FieldValue Language
dc.contributor.authorPadia, Ravi N.en
dc.date.accessioned2014-08-29T02:45:50Z-
dc.date.available2014-08-29T02:45:50Z-
dc.date.issued2014-04-
dc.identifier.urihttp://hdl.handle.net/10675.2/325521-
dc.description.abstractPost translational modifications (PTMs) such as phosphorylation, acetylation, ubiquitination, methylation, SUMOylation etc. serve to add another level of complexity and functional diversity to the proteome. These PTMs serve to generate a distinct signal which can then regulate the functionality of the protein harboring one or more of these PTMs and hence ultimately regulating the associated signaling/biological pathway. Some of the ways in which PTMs can bring about the change in the functionality of proteome is by influencing the sub-cellular localization of proteins, protein-protein, protein-DNA, protein-RNA interactions, activity of enzymes, protein turnover, oligomerization of proteins etc. Further, a combination of two or more PTMs can bring about another layer of regulation where presence of a particular combination of PTMs is obligatory to elicit the regulatory message (Yang and Seto 2008a).en
dc.language.isoenen
dc.relation.urlhttp://ezproxy.gru.edu/login?url=http://search.proquest.com/docview/1527018534?accountid=12365en
dc.rightsCopyright protected. Unauthorized reproduction or use beyond the exceptions granted by the Fair Use clause of U.S. Copyright law may violate federal law.-
dc.subjectSirtuinen
dc.subjectSir2Pen
dc.subjectPeroxisome isolationen
dc.subject293FT cellsen
dc.subjectGNPATen
dc.subjectPost-translational modificationen
dc.subjectLysine deacetylasesen
dc.titleNovel Peroxisomal Localization of Sirtuin 3 and its Biological Implicationsen
dc.typeDissertationen
dc.description.advisorThangaraju, Muthusamy-
dc.description.committeeGanapathy, Vadivel; Schoenlein, Patricia; Browning, Darren D.; Huang, Shuang-
dc.description.degreeDoctor of Philosophy (Ph.D.)-
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